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Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy

The interplay between p53 and RAS signaling regulates cancer chemoresistance, but the detailed mechanism is unclear. In this study, we investigated the interactive effects of p53 and RAS on ovarian cancer cisplatin resistance to explore the potential therapeutic targets. Methods: An inducible p53 an...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiaofei, Qi, Zihao, Yin, Huijing, Yang, Gong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401400/ https://www.ncbi.nlm.nih.gov/pubmed/30867818 http://dx.doi.org/10.7150/thno.29673

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