Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

Rationale: Platelets are increasingly recognized as mediators of tumor growth and metastasis. Hypothesizing that activated platelets in the tumor microenvironment provide a targeting epitope for tumor-directed chemotherapy, we developed an antibody-drug conjugate (ADC), comprised of a single-chain a...

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Detalles Bibliográficos
Autores principales: Yap, May Lin, McFadyen, James D, Wang, Xiaowei, Ziegler, Melanie, Chen, Yung-Chih, Willcox, Abbey, Nowell, Cameron J, Scott, Andrew M, Sloan, Erica K, Hogarth, P Mark, Pietersz, Geoffrey A, Peter, Karlheinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401411/
https://www.ncbi.nlm.nih.gov/pubmed/30867822
http://dx.doi.org/10.7150/thno.29146

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