Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?

The high degree of conservation of CD8 T cell epitopes of influenza A virus (IAV) may allow for the development of T cell-inducing vaccines that provide protection across different strains and subtypes. This conservation is not fully explained by functional constraint, since an additional mutation(s...

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Detalles Bibliográficos
Autores principales: Li, Zheng-Rong Tiger, Zarnitsyna, Veronika I., Lowen, Anice C., Weissman, Daniel, Koelle, Katia, Kohlmeier, Jacob E., Antia, Rustom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401462/
https://www.ncbi.nlm.nih.gov/pubmed/30626684
http://dx.doi.org/10.1128/JVI.01534-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401462/
https://www.ncbi.nlm.nih.gov/pubmed/30626684
http://dx.doi.org/10.1128/JVI.01534-18

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