Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review

Marchiafava–Bignami disease (MBD) is a rare condition characterized by demyelination, necrosis and atrophy of the corpus callosum (CC), and mainly associated with alcoholism. MBD may present with various clinical manifestations. Brain magnetic resonance imaging (MRI) scan is important in prompt diag...

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Detalles Bibliográficos
Autores principales: Wang, Zhiqin, Wang, Jianfeng, Yi, Fang, Zhou, Lin, Zhou, Yafang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401522/
https://www.ncbi.nlm.nih.gov/pubmed/30873016
http://dx.doi.org/10.3389/fnhum.2019.00079
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author Wang, Zhiqin
Wang, Jianfeng
Yi, Fang
Zhou, Lin
Zhou, Yafang
author_facet Wang, Zhiqin
Wang, Jianfeng
Yi, Fang
Zhou, Lin
Zhou, Yafang
author_sort Wang, Zhiqin
collection PubMed
description Marchiafava–Bignami disease (MBD) is a rare condition characterized by demyelination, necrosis and atrophy of the corpus callosum (CC), and mainly associated with alcoholism. MBD may present with various clinical manifestations. Brain magnetic resonance imaging (MRI) scan is important in prompt diagnosis and treatment of MBD. Here we reported a case of MBD and reviewed literature about the usage of gadolinium-enhanced MRI in MBD. Gadolinium enhancement may indicate a condition at risk of developing necrosis. We therefore recommend a contrast-enhanced MRI study in severe alcoholics with suspected diagnosis of MBD.
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spelling pubmed-64015222019-03-14 Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review Wang, Zhiqin Wang, Jianfeng Yi, Fang Zhou, Lin Zhou, Yafang Front Hum Neurosci Neuroscience Marchiafava–Bignami disease (MBD) is a rare condition characterized by demyelination, necrosis and atrophy of the corpus callosum (CC), and mainly associated with alcoholism. MBD may present with various clinical manifestations. Brain magnetic resonance imaging (MRI) scan is important in prompt diagnosis and treatment of MBD. Here we reported a case of MBD and reviewed literature about the usage of gadolinium-enhanced MRI in MBD. Gadolinium enhancement may indicate a condition at risk of developing necrosis. We therefore recommend a contrast-enhanced MRI study in severe alcoholics with suspected diagnosis of MBD. Frontiers Media S.A. 2019-02-27 /pmc/articles/PMC6401522/ /pubmed/30873016 http://dx.doi.org/10.3389/fnhum.2019.00079 Text en Copyright © 2019 Wang, Wang, Yi, Zhou and Zhou. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Wang, Zhiqin
Wang, Jianfeng
Yi, Fang
Zhou, Lin
Zhou, Yafang
Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review
title Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review
title_full Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review
title_fullStr Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review
title_full_unstemmed Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review
title_short Gadolinium Enhancement May Indicate a Condition at Risk of Developing Necrosis in Marchiafava–Bignami Disease: A Case Report and Literature Review
title_sort gadolinium enhancement may indicate a condition at risk of developing necrosis in marchiafava–bignami disease: a case report and literature review
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401522/
https://www.ncbi.nlm.nih.gov/pubmed/30873016
http://dx.doi.org/10.3389/fnhum.2019.00079
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