Cargando…
Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains
Adult neurogenesis has been extensively studied in rodent animals, with distinct niches found in the hippocampus and subventricular zone (SVZ). In non-human primates and human postmortem samples, there has been heated debate regarding adult neurogenesis, but it is largely agreed that the rate of adu...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401632/ https://www.ncbi.nlm.nih.gov/pubmed/30872991 http://dx.doi.org/10.3389/fnins.2019.00131 |
_version_ | 1783400185021333504 |
---|---|
author | Lei, Wenliang Li, Wen Ge, Longjiao Chen, Gong |
author_facet | Lei, Wenliang Li, Wen Ge, Longjiao Chen, Gong |
author_sort | Lei, Wenliang |
collection | PubMed |
description | Adult neurogenesis has been extensively studied in rodent animals, with distinct niches found in the hippocampus and subventricular zone (SVZ). In non-human primates and human postmortem samples, there has been heated debate regarding adult neurogenesis, but it is largely agreed that the rate of adult neurogenesis is much reduced comparing to rodents. The limited adult neurogenesis may partly explain why human brains do not have self-repair capability after injury or disease. A new technology called “in vivo cell conversion” has been invented to convert brain internal glial cells in the injury areas directly into functional new neurons to replenish the lost neurons. Because glial cells are abundant throughout the brain and spinal cord, such engineered glia-to-neuron conversion technology can be applied throughout the central nervous system (CNS) to regenerate new neurons. Thus, compared to cell transplantation or the non-engineered adult neurogenesis, in vivo engineered neuroregeneration technology can provide a large number of functional new neurons in situ to repair damaged brain and spinal cord. |
format | Online Article Text |
id | pubmed-6401632 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-64016322019-03-14 Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains Lei, Wenliang Li, Wen Ge, Longjiao Chen, Gong Front Neurosci Neuroscience Adult neurogenesis has been extensively studied in rodent animals, with distinct niches found in the hippocampus and subventricular zone (SVZ). In non-human primates and human postmortem samples, there has been heated debate regarding adult neurogenesis, but it is largely agreed that the rate of adult neurogenesis is much reduced comparing to rodents. The limited adult neurogenesis may partly explain why human brains do not have self-repair capability after injury or disease. A new technology called “in vivo cell conversion” has been invented to convert brain internal glial cells in the injury areas directly into functional new neurons to replenish the lost neurons. Because glial cells are abundant throughout the brain and spinal cord, such engineered glia-to-neuron conversion technology can be applied throughout the central nervous system (CNS) to regenerate new neurons. Thus, compared to cell transplantation or the non-engineered adult neurogenesis, in vivo engineered neuroregeneration technology can provide a large number of functional new neurons in situ to repair damaged brain and spinal cord. Frontiers Media S.A. 2019-02-21 /pmc/articles/PMC6401632/ /pubmed/30872991 http://dx.doi.org/10.3389/fnins.2019.00131 Text en Copyright © 2019 Lei, Li, Ge and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Lei, Wenliang Li, Wen Ge, Longjiao Chen, Gong Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains |
title | Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains |
title_full | Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains |
title_fullStr | Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains |
title_full_unstemmed | Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains |
title_short | Non-engineered and Engineered Adult Neurogenesis in Mammalian Brains |
title_sort | non-engineered and engineered adult neurogenesis in mammalian brains |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401632/ https://www.ncbi.nlm.nih.gov/pubmed/30872991 http://dx.doi.org/10.3389/fnins.2019.00131 |
work_keys_str_mv | AT leiwenliang nonengineeredandengineeredadultneurogenesisinmammalianbrains AT liwen nonengineeredandengineeredadultneurogenesisinmammalianbrains AT gelongjiao nonengineeredandengineeredadultneurogenesisinmammalianbrains AT chengong nonengineeredandengineeredadultneurogenesisinmammalianbrains |