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Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View

Dendritic cells (DC) are a diverse group of leukocytes responsible for bridging innate and adaptive immunity. Despite their functional versatility, DCs exist primarily in two basic functional states: immature and mature. A large body of evidence suggests that upon interactions with pathogens, DCs un...

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Autores principales: Tibúrcio, Rafael, Nunes, Sara, Nunes, Ivanéia, Rosa Ampuero, Mariana, Silva, Icaro Bonyek, Lima, Reinan, Machado Tavares, Natalia, Brodskyn, Cláudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401646/
https://www.ncbi.nlm.nih.gov/pubmed/30873156
http://dx.doi.org/10.3389/fimmu.2019.00227
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author Tibúrcio, Rafael
Nunes, Sara
Nunes, Ivanéia
Rosa Ampuero, Mariana
Silva, Icaro Bonyek
Lima, Reinan
Machado Tavares, Natalia
Brodskyn, Cláudia
author_facet Tibúrcio, Rafael
Nunes, Sara
Nunes, Ivanéia
Rosa Ampuero, Mariana
Silva, Icaro Bonyek
Lima, Reinan
Machado Tavares, Natalia
Brodskyn, Cláudia
author_sort Tibúrcio, Rafael
collection PubMed
description Dendritic cells (DC) are a diverse group of leukocytes responsible for bridging innate and adaptive immunity. Despite their functional versatility, DCs exist primarily in two basic functional states: immature and mature. A large body of evidence suggests that upon interactions with pathogens, DCs undergo intricate cellular processes that culminate in their activation, which is paramount to the orchestration of effective immune responses against Leishmania parasites. Herein we offer a concise review of the emerging hallmarks of DCs activation in leishmaniasis as well as a comprehensive discussion of the following underlying molecular events: DC-Leishmania interaction, antigen uptake, costimulatory molecule expression, parasite ability to affect DC migration, antigen presentation, metabolic reprogramming, and epigenetic alterations.
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spelling pubmed-64016462019-03-14 Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View Tibúrcio, Rafael Nunes, Sara Nunes, Ivanéia Rosa Ampuero, Mariana Silva, Icaro Bonyek Lima, Reinan Machado Tavares, Natalia Brodskyn, Cláudia Front Immunol Immunology Dendritic cells (DC) are a diverse group of leukocytes responsible for bridging innate and adaptive immunity. Despite their functional versatility, DCs exist primarily in two basic functional states: immature and mature. A large body of evidence suggests that upon interactions with pathogens, DCs undergo intricate cellular processes that culminate in their activation, which is paramount to the orchestration of effective immune responses against Leishmania parasites. Herein we offer a concise review of the emerging hallmarks of DCs activation in leishmaniasis as well as a comprehensive discussion of the following underlying molecular events: DC-Leishmania interaction, antigen uptake, costimulatory molecule expression, parasite ability to affect DC migration, antigen presentation, metabolic reprogramming, and epigenetic alterations. Frontiers Media S.A. 2019-02-22 /pmc/articles/PMC6401646/ /pubmed/30873156 http://dx.doi.org/10.3389/fimmu.2019.00227 Text en Copyright © 2019 Tibúrcio, Nunes, Nunes, Rosa Ampuero, Silva, Lima, Machado Tavares and Brodskyn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Tibúrcio, Rafael
Nunes, Sara
Nunes, Ivanéia
Rosa Ampuero, Mariana
Silva, Icaro Bonyek
Lima, Reinan
Machado Tavares, Natalia
Brodskyn, Cláudia
Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View
title Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View
title_full Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View
title_fullStr Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View
title_full_unstemmed Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View
title_short Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View
title_sort molecular aspects of dendritic cell activation in leishmaniasis: an immunobiological view
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401646/
https://www.ncbi.nlm.nih.gov/pubmed/30873156
http://dx.doi.org/10.3389/fimmu.2019.00227
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