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Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces

To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(ε-caprolactone), as well as tw...

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Autores principales: Korzhikov-Vlakh, Viktor, Averianov, Ilia, Sinitsyna, Ekaterina, Nashchekina, Yuliya, Polyakov, Dmitry, Guryanov, Ivan, Lavrentieva, Antonina, Raddatz, Lukas, Korzhikova-Vlakh, Evgenia, Scheper, Thomas, Tennikova, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401704/
https://www.ncbi.nlm.nih.gov/pubmed/30961224
http://dx.doi.org/10.3390/polym10121299
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author Korzhikov-Vlakh, Viktor
Averianov, Ilia
Sinitsyna, Ekaterina
Nashchekina, Yuliya
Polyakov, Dmitry
Guryanov, Ivan
Lavrentieva, Antonina
Raddatz, Lukas
Korzhikova-Vlakh, Evgenia
Scheper, Thomas
Tennikova, Tatiana
author_facet Korzhikov-Vlakh, Viktor
Averianov, Ilia
Sinitsyna, Ekaterina
Nashchekina, Yuliya
Polyakov, Dmitry
Guryanov, Ivan
Lavrentieva, Antonina
Raddatz, Lukas
Korzhikova-Vlakh, Evgenia
Scheper, Thomas
Tennikova, Tatiana
author_sort Korzhikov-Vlakh, Viktor
collection PubMed
description To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(ε-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-d-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands (“self-peptide” or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems.
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spelling pubmed-64017042019-04-02 Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces Korzhikov-Vlakh, Viktor Averianov, Ilia Sinitsyna, Ekaterina Nashchekina, Yuliya Polyakov, Dmitry Guryanov, Ivan Lavrentieva, Antonina Raddatz, Lukas Korzhikova-Vlakh, Evgenia Scheper, Thomas Tennikova, Tatiana Polymers (Basel) Article To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(ε-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-d-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands (“self-peptide” or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems. MDPI 2018-11-23 /pmc/articles/PMC6401704/ /pubmed/30961224 http://dx.doi.org/10.3390/polym10121299 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Korzhikov-Vlakh, Viktor
Averianov, Ilia
Sinitsyna, Ekaterina
Nashchekina, Yuliya
Polyakov, Dmitry
Guryanov, Ivan
Lavrentieva, Antonina
Raddatz, Lukas
Korzhikova-Vlakh, Evgenia
Scheper, Thomas
Tennikova, Tatiana
Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces
title Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces
title_full Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces
title_fullStr Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces
title_full_unstemmed Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces
title_short Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces
title_sort novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401704/
https://www.ncbi.nlm.nih.gov/pubmed/30961224
http://dx.doi.org/10.3390/polym10121299
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