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Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces
To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(ε-caprolactone), as well as tw...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401704/ https://www.ncbi.nlm.nih.gov/pubmed/30961224 http://dx.doi.org/10.3390/polym10121299 |
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author | Korzhikov-Vlakh, Viktor Averianov, Ilia Sinitsyna, Ekaterina Nashchekina, Yuliya Polyakov, Dmitry Guryanov, Ivan Lavrentieva, Antonina Raddatz, Lukas Korzhikova-Vlakh, Evgenia Scheper, Thomas Tennikova, Tatiana |
author_facet | Korzhikov-Vlakh, Viktor Averianov, Ilia Sinitsyna, Ekaterina Nashchekina, Yuliya Polyakov, Dmitry Guryanov, Ivan Lavrentieva, Antonina Raddatz, Lukas Korzhikova-Vlakh, Evgenia Scheper, Thomas Tennikova, Tatiana |
author_sort | Korzhikov-Vlakh, Viktor |
collection | PubMed |
description | To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(ε-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-d-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands (“self-peptide” or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems. |
format | Online Article Text |
id | pubmed-6401704 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64017042019-04-02 Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces Korzhikov-Vlakh, Viktor Averianov, Ilia Sinitsyna, Ekaterina Nashchekina, Yuliya Polyakov, Dmitry Guryanov, Ivan Lavrentieva, Antonina Raddatz, Lukas Korzhikova-Vlakh, Evgenia Scheper, Thomas Tennikova, Tatiana Polymers (Basel) Article To form modern materials with biomimic surfaces, the novel pathway for surface functionalization with specific ligands of well-known and widely used polyester-based rigid media was developed and optimized. Two types of material bases, namely, poly(lactic acid) and poly(ε-caprolactone), as well as two types of material design, e.g., supermacroporous matrices and nanoparticles (NPs), were modified via covalent attachment of preliminary oxidized polyvinylsaccharide poly(2-deoxy-N-methacryloylamido-d-glucose) (PMAG). This polymer, being highly biocompatible and bioinspired, was used to enhance hydrophilicity of the polymer surface and to provide the elevated concentration of reactive groups required for covalent binding of bioligands of choice. The specialties of the interaction of PMAG and its preliminary formed bioconjugates with a chemically activated polyester surface were studied and thoroughly discussed. The supermacroporous materials modified with cell adhesion motifs and Arg-Gly-Asp-containing peptide (RGD-peptide) were tested in the experiments on bone tissue engineering. In turn, the NPs were modified with bioligands (“self-peptide” or camel antibodies) to control their phagocytosis that can be important, for example, for the preparation of drug delivery systems. MDPI 2018-11-23 /pmc/articles/PMC6401704/ /pubmed/30961224 http://dx.doi.org/10.3390/polym10121299 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Korzhikov-Vlakh, Viktor Averianov, Ilia Sinitsyna, Ekaterina Nashchekina, Yuliya Polyakov, Dmitry Guryanov, Ivan Lavrentieva, Antonina Raddatz, Lukas Korzhikova-Vlakh, Evgenia Scheper, Thomas Tennikova, Tatiana Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces |
title | Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces |
title_full | Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces |
title_fullStr | Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces |
title_full_unstemmed | Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces |
title_short | Novel Pathway for Efficient Covalent Modification of Polyester Materials of Different Design to Prepare Biomimetic Surfaces |
title_sort | novel pathway for efficient covalent modification of polyester materials of different design to prepare biomimetic surfaces |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401704/ https://www.ncbi.nlm.nih.gov/pubmed/30961224 http://dx.doi.org/10.3390/polym10121299 |
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