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Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed

Galactomannan, a water-soluble polymer in the cell wall of leguminous plants, has been proven to possess anticancer and antioxidative activity. In this work, galactomannan with different molecular weights (GM-40 and GM-65) was obtained from Sesbania seeds and synthesized into galactomannan–iron(III)...

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Autores principales: Huang, Caoxing, Tao, Yuheng, Li, Min, Zhang, Weiyu, Fan, Yimin, Yong, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401707/
https://www.ncbi.nlm.nih.gov/pubmed/30960012
http://dx.doi.org/10.3390/polym11010028
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author Huang, Caoxing
Tao, Yuheng
Li, Min
Zhang, Weiyu
Fan, Yimin
Yong, Qiang
author_facet Huang, Caoxing
Tao, Yuheng
Li, Min
Zhang, Weiyu
Fan, Yimin
Yong, Qiang
author_sort Huang, Caoxing
collection PubMed
description Galactomannan, a water-soluble polymer in the cell wall of leguminous plants, has been proven to possess anticancer and antioxidative activity. In this work, galactomannan with different molecular weights (GM-40 and GM-65) was obtained from Sesbania seeds and synthesized into galactomannan–iron(III) complexes, which are termed as GM-40-Fe and GM-65-Fe, respectively. These galactomannan–iron(III) complexes are intended to function as organic iron supplements to treat iron deficiency with the added benefit of antioxidative activity. The prepared galactomannan–iron(III) complexes were characterized for chemical composition, morphology, antioxidant capacity, and bioavailability in vitro. The results showed that galactomannan–iron(III) complexes could be produced with iron contents as high as 65.4 mg/g. Antioxidant assays indicated that both GM-40-Fe and GM-65-Fe exhibited antioxidant activities for scavenging radicals in vitro. The iron release/bioavailability assays showed that the iron was easily released into artificial gastric and intestinal juices, resulting in iron release rates of 88–94% over 300 min. These results suggest that galactomannan–iron(III) complexes synthesized from Sesbania seed polysaccharides are capable of being administered as organic iron supplements to patients with iron deficiency.
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spelling pubmed-64017072019-04-02 Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed Huang, Caoxing Tao, Yuheng Li, Min Zhang, Weiyu Fan, Yimin Yong, Qiang Polymers (Basel) Article Galactomannan, a water-soluble polymer in the cell wall of leguminous plants, has been proven to possess anticancer and antioxidative activity. In this work, galactomannan with different molecular weights (GM-40 and GM-65) was obtained from Sesbania seeds and synthesized into galactomannan–iron(III) complexes, which are termed as GM-40-Fe and GM-65-Fe, respectively. These galactomannan–iron(III) complexes are intended to function as organic iron supplements to treat iron deficiency with the added benefit of antioxidative activity. The prepared galactomannan–iron(III) complexes were characterized for chemical composition, morphology, antioxidant capacity, and bioavailability in vitro. The results showed that galactomannan–iron(III) complexes could be produced with iron contents as high as 65.4 mg/g. Antioxidant assays indicated that both GM-40-Fe and GM-65-Fe exhibited antioxidant activities for scavenging radicals in vitro. The iron release/bioavailability assays showed that the iron was easily released into artificial gastric and intestinal juices, resulting in iron release rates of 88–94% over 300 min. These results suggest that galactomannan–iron(III) complexes synthesized from Sesbania seed polysaccharides are capable of being administered as organic iron supplements to patients with iron deficiency. MDPI 2018-12-25 /pmc/articles/PMC6401707/ /pubmed/30960012 http://dx.doi.org/10.3390/polym11010028 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Caoxing
Tao, Yuheng
Li, Min
Zhang, Weiyu
Fan, Yimin
Yong, Qiang
Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed
title Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed
title_full Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed
title_fullStr Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed
title_full_unstemmed Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed
title_short Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed
title_sort synthesis and characterization of an antioxidative galactomannan–iron(iii) complex from sesbania seed
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401707/
https://www.ncbi.nlm.nih.gov/pubmed/30960012
http://dx.doi.org/10.3390/polym11010028
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