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Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed
Galactomannan, a water-soluble polymer in the cell wall of leguminous plants, has been proven to possess anticancer and antioxidative activity. In this work, galactomannan with different molecular weights (GM-40 and GM-65) was obtained from Sesbania seeds and synthesized into galactomannan–iron(III)...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401707/ https://www.ncbi.nlm.nih.gov/pubmed/30960012 http://dx.doi.org/10.3390/polym11010028 |
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author | Huang, Caoxing Tao, Yuheng Li, Min Zhang, Weiyu Fan, Yimin Yong, Qiang |
author_facet | Huang, Caoxing Tao, Yuheng Li, Min Zhang, Weiyu Fan, Yimin Yong, Qiang |
author_sort | Huang, Caoxing |
collection | PubMed |
description | Galactomannan, a water-soluble polymer in the cell wall of leguminous plants, has been proven to possess anticancer and antioxidative activity. In this work, galactomannan with different molecular weights (GM-40 and GM-65) was obtained from Sesbania seeds and synthesized into galactomannan–iron(III) complexes, which are termed as GM-40-Fe and GM-65-Fe, respectively. These galactomannan–iron(III) complexes are intended to function as organic iron supplements to treat iron deficiency with the added benefit of antioxidative activity. The prepared galactomannan–iron(III) complexes were characterized for chemical composition, morphology, antioxidant capacity, and bioavailability in vitro. The results showed that galactomannan–iron(III) complexes could be produced with iron contents as high as 65.4 mg/g. Antioxidant assays indicated that both GM-40-Fe and GM-65-Fe exhibited antioxidant activities for scavenging radicals in vitro. The iron release/bioavailability assays showed that the iron was easily released into artificial gastric and intestinal juices, resulting in iron release rates of 88–94% over 300 min. These results suggest that galactomannan–iron(III) complexes synthesized from Sesbania seed polysaccharides are capable of being administered as organic iron supplements to patients with iron deficiency. |
format | Online Article Text |
id | pubmed-6401707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64017072019-04-02 Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed Huang, Caoxing Tao, Yuheng Li, Min Zhang, Weiyu Fan, Yimin Yong, Qiang Polymers (Basel) Article Galactomannan, a water-soluble polymer in the cell wall of leguminous plants, has been proven to possess anticancer and antioxidative activity. In this work, galactomannan with different molecular weights (GM-40 and GM-65) was obtained from Sesbania seeds and synthesized into galactomannan–iron(III) complexes, which are termed as GM-40-Fe and GM-65-Fe, respectively. These galactomannan–iron(III) complexes are intended to function as organic iron supplements to treat iron deficiency with the added benefit of antioxidative activity. The prepared galactomannan–iron(III) complexes were characterized for chemical composition, morphology, antioxidant capacity, and bioavailability in vitro. The results showed that galactomannan–iron(III) complexes could be produced with iron contents as high as 65.4 mg/g. Antioxidant assays indicated that both GM-40-Fe and GM-65-Fe exhibited antioxidant activities for scavenging radicals in vitro. The iron release/bioavailability assays showed that the iron was easily released into artificial gastric and intestinal juices, resulting in iron release rates of 88–94% over 300 min. These results suggest that galactomannan–iron(III) complexes synthesized from Sesbania seed polysaccharides are capable of being administered as organic iron supplements to patients with iron deficiency. MDPI 2018-12-25 /pmc/articles/PMC6401707/ /pubmed/30960012 http://dx.doi.org/10.3390/polym11010028 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Caoxing Tao, Yuheng Li, Min Zhang, Weiyu Fan, Yimin Yong, Qiang Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed |
title | Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed |
title_full | Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed |
title_fullStr | Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed |
title_full_unstemmed | Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed |
title_short | Synthesis and Characterization of an Antioxidative Galactomannan–Iron(III) Complex from Sesbania Seed |
title_sort | synthesis and characterization of an antioxidative galactomannan–iron(iii) complex from sesbania seed |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401707/ https://www.ncbi.nlm.nih.gov/pubmed/30960012 http://dx.doi.org/10.3390/polym11010028 |
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