Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue

Photocrosslinked gelatin methacryloyl (GelMA) hydrogels have attracted great concern in the biomedical field because of their good biocompatibility and tunable physicochemical properties. Herein, different approaches to synthesize GelMA were introduced, especially, the typical method using UV light...

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Detalles Bibliográficos
Autores principales: Sun, Mingyue, Sun, Xiaoting, Wang, Ziyuan, Guo, Shuyu, Yu, Guangjiao, Yang, Huazhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401825/
https://www.ncbi.nlm.nih.gov/pubmed/30961215
http://dx.doi.org/10.3390/polym10111290
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author Sun, Mingyue
Sun, Xiaoting
Wang, Ziyuan
Guo, Shuyu
Yu, Guangjiao
Yang, Huazhe
author_facet Sun, Mingyue
Sun, Xiaoting
Wang, Ziyuan
Guo, Shuyu
Yu, Guangjiao
Yang, Huazhe
author_sort Sun, Mingyue
collection PubMed
description Photocrosslinked gelatin methacryloyl (GelMA) hydrogels have attracted great concern in the biomedical field because of their good biocompatibility and tunable physicochemical properties. Herein, different approaches to synthesize GelMA were introduced, especially, the typical method using UV light to crosslink the gelatin-methacrylic anhydride (MA) precursor was introduced in detail. In addition, the traditional and cutting-edge technologies to characterize the properties of GelMA hydrogels and GelMA prepolymer were also overviewed and compared. Furthermore, the applications of GelMA hydrogels in cell culture and tissue engineering especially in the load-bearing tissue (bone and cartilage) were summarized, followed by concluding remarks.
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spelling pubmed-64018252019-04-02 Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue Sun, Mingyue Sun, Xiaoting Wang, Ziyuan Guo, Shuyu Yu, Guangjiao Yang, Huazhe Polymers (Basel) Review Photocrosslinked gelatin methacryloyl (GelMA) hydrogels have attracted great concern in the biomedical field because of their good biocompatibility and tunable physicochemical properties. Herein, different approaches to synthesize GelMA were introduced, especially, the typical method using UV light to crosslink the gelatin-methacrylic anhydride (MA) precursor was introduced in detail. In addition, the traditional and cutting-edge technologies to characterize the properties of GelMA hydrogels and GelMA prepolymer were also overviewed and compared. Furthermore, the applications of GelMA hydrogels in cell culture and tissue engineering especially in the load-bearing tissue (bone and cartilage) were summarized, followed by concluding remarks. MDPI 2018-11-21 /pmc/articles/PMC6401825/ /pubmed/30961215 http://dx.doi.org/10.3390/polym10111290 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sun, Mingyue
Sun, Xiaoting
Wang, Ziyuan
Guo, Shuyu
Yu, Guangjiao
Yang, Huazhe
Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_full Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_fullStr Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_full_unstemmed Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_short Synthesis and Properties of Gelatin Methacryloyl (GelMA) Hydrogels and Their Recent Applications in Load-Bearing Tissue
title_sort synthesis and properties of gelatin methacryloyl (gelma) hydrogels and their recent applications in load-bearing tissue
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401825/
https://www.ncbi.nlm.nih.gov/pubmed/30961215
http://dx.doi.org/10.3390/polym10111290
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