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Phase-Field Modeling of Freeze Concentration of Protein Solutions

Bulk solutions of therapeutic proteins are often frozen for long-term storage. During the freezing process, proteins in liquid solution redistribute and segregate in the interstitial space between ice crystals. This is due to solute exclusion from ice crystals, higher viscosity of the concentrated s...

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Detalles Bibliográficos
Autores principales:	Fan, Tai-Hsi, Li, Ji-Qin, Minatovicz, Bruna, Soha, Elizabeth, Sun, Li, Patel, Sajal, Chaudhuri, Bodhisattwa, Bogner, Robin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401895/ https://www.ncbi.nlm.nih.gov/pubmed/30959994 http://dx.doi.org/10.3390/polym11010010

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