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Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol
BACKGROUND: The HIV/AIDS pandemic has struck regions, countries, and populations in different ways. With the introduction of antiretroviral drugs, people living with HIV (PLHIV) have a much better prognosis, even though there are still many new infections in young women. The role of widespread antir...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402083/ https://www.ncbi.nlm.nih.gov/pubmed/30837002 http://dx.doi.org/10.1186/s13643-019-0982-z |
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author | Chibawara, Trust Mbuagbaw, Lawrence Kitenge, Marcel Nyasulu, Peter |
author_facet | Chibawara, Trust Mbuagbaw, Lawrence Kitenge, Marcel Nyasulu, Peter |
author_sort | Chibawara, Trust |
collection | PubMed |
description | BACKGROUND: The HIV/AIDS pandemic has struck regions, countries, and populations in different ways. With the introduction of antiretroviral drugs, people living with HIV (PLHIV) have a much better prognosis, even though there are still many new infections in young women. The role of widespread antiretroviral therapy (ART) on the incidence of HIV in young women is unknown. METHODS: We will conduct a comprehensive search of MEDLINE (PubMed), Excerpta Medica database (EMBASE), Scopus, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), World Health Organization’s (WHO’s) library database, Latin American and Caribbean Health Sciences Literature (LILACS), conference abstracts, and gray literature sources to identify any relevant literature. We will include randomized and non-randomized clinical trials and cohort studies in which ART was offered to adults aged 18 and above reporting outcomes in females aged 15 to 24 years. The outcomes of interest are HIV incidence, ART initiation, adherence, retention, and viral load suppression. We will screen titles, abstracts, and the full texts of relevant articles in duplicate. Disagreements will be resolved by consensus. We will extract data on the risk of HIV infection in younger females after the use of ART in the adult population. DISCUSSION: To our knowledge, this is the first systematic review to look at the impact of ART use among adults on HIV incidence in young women. The results of this review will be used in a modeling study to simulate the effects of using ART as an effective tool to prevent sexual transmission of HIV to young women. Our findings will inform the treatment-as-prevention (TasP) strategy to reduce new HIV infections among young women. SYSTEMATIC REVIEW REGISTRATION: The systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42018099174. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13643-019-0982-z) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6402083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64020832019-03-14 Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol Chibawara, Trust Mbuagbaw, Lawrence Kitenge, Marcel Nyasulu, Peter Syst Rev Protocol BACKGROUND: The HIV/AIDS pandemic has struck regions, countries, and populations in different ways. With the introduction of antiretroviral drugs, people living with HIV (PLHIV) have a much better prognosis, even though there are still many new infections in young women. The role of widespread antiretroviral therapy (ART) on the incidence of HIV in young women is unknown. METHODS: We will conduct a comprehensive search of MEDLINE (PubMed), Excerpta Medica database (EMBASE), Scopus, Google Scholar, Cochrane Central Register of Controlled Trials (CENTRAL), World Health Organization’s (WHO’s) library database, Latin American and Caribbean Health Sciences Literature (LILACS), conference abstracts, and gray literature sources to identify any relevant literature. We will include randomized and non-randomized clinical trials and cohort studies in which ART was offered to adults aged 18 and above reporting outcomes in females aged 15 to 24 years. The outcomes of interest are HIV incidence, ART initiation, adherence, retention, and viral load suppression. We will screen titles, abstracts, and the full texts of relevant articles in duplicate. Disagreements will be resolved by consensus. We will extract data on the risk of HIV infection in younger females after the use of ART in the adult population. DISCUSSION: To our knowledge, this is the first systematic review to look at the impact of ART use among adults on HIV incidence in young women. The results of this review will be used in a modeling study to simulate the effects of using ART as an effective tool to prevent sexual transmission of HIV to young women. Our findings will inform the treatment-as-prevention (TasP) strategy to reduce new HIV infections among young women. SYSTEMATIC REVIEW REGISTRATION: The systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42018099174. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13643-019-0982-z) contains supplementary material, which is available to authorized users. BioMed Central 2019-03-05 /pmc/articles/PMC6402083/ /pubmed/30837002 http://dx.doi.org/10.1186/s13643-019-0982-z Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Protocol Chibawara, Trust Mbuagbaw, Lawrence Kitenge, Marcel Nyasulu, Peter Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol |
title | Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol |
title_full | Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol |
title_fullStr | Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol |
title_full_unstemmed | Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol |
title_short | Effects of antiretroviral therapy in HIV-positive adults on new HIV infections among young women: a systematic review protocol |
title_sort | effects of antiretroviral therapy in hiv-positive adults on new hiv infections among young women: a systematic review protocol |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402083/ https://www.ncbi.nlm.nih.gov/pubmed/30837002 http://dx.doi.org/10.1186/s13643-019-0982-z |
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