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The ancient sarcomeric myosins found in specialized muscles

Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order to meet the demands of the muscle. The sarcomeric myosin heavy chain (MYH) genes expressed...

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Autores principales: Lee, Lindsey A., Karabina, Anastasia, Broadwell, Lindsey J., Leinwand, Leslie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402096/
https://www.ncbi.nlm.nih.gov/pubmed/30836986
http://dx.doi.org/10.1186/s13395-019-0192-3
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author Lee, Lindsey A.
Karabina, Anastasia
Broadwell, Lindsey J.
Leinwand, Leslie A.
author_facet Lee, Lindsey A.
Karabina, Anastasia
Broadwell, Lindsey J.
Leinwand, Leslie A.
author_sort Lee, Lindsey A.
collection PubMed
description Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order to meet the demands of the muscle. The sarcomeric myosin heavy chain (MYH) genes expressed in the major cardiac and skeletal muscles have been studied for decades. However, three ancient myosins, MYH7b, MYH15, and MYH16, remained uncharacterized due to their unique expression patterns in common mammalian model organisms and due to their relatively recent discovery in these genomes. This article reviews the literature surrounding these three ancient sarcomeric myosins and the specialized muscles in which they are expressed. Further study of these ancient myosins and how they contribute to the functions of the specialized muscles may provide novel insight into the history of striated muscle evolution.
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spelling pubmed-64020962019-03-14 The ancient sarcomeric myosins found in specialized muscles Lee, Lindsey A. Karabina, Anastasia Broadwell, Lindsey J. Leinwand, Leslie A. Skelet Muscle Review Striated muscles express an array of sarcomeric myosin motors that are tuned to accomplish specific tasks. Each myosin isoform found in muscle fibers confers unique contractile properties to the fiber in order to meet the demands of the muscle. The sarcomeric myosin heavy chain (MYH) genes expressed in the major cardiac and skeletal muscles have been studied for decades. However, three ancient myosins, MYH7b, MYH15, and MYH16, remained uncharacterized due to their unique expression patterns in common mammalian model organisms and due to their relatively recent discovery in these genomes. This article reviews the literature surrounding these three ancient sarcomeric myosins and the specialized muscles in which they are expressed. Further study of these ancient myosins and how they contribute to the functions of the specialized muscles may provide novel insight into the history of striated muscle evolution. BioMed Central 2019-03-05 /pmc/articles/PMC6402096/ /pubmed/30836986 http://dx.doi.org/10.1186/s13395-019-0192-3 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Lee, Lindsey A.
Karabina, Anastasia
Broadwell, Lindsey J.
Leinwand, Leslie A.
The ancient sarcomeric myosins found in specialized muscles
title The ancient sarcomeric myosins found in specialized muscles
title_full The ancient sarcomeric myosins found in specialized muscles
title_fullStr The ancient sarcomeric myosins found in specialized muscles
title_full_unstemmed The ancient sarcomeric myosins found in specialized muscles
title_short The ancient sarcomeric myosins found in specialized muscles
title_sort ancient sarcomeric myosins found in specialized muscles
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402096/
https://www.ncbi.nlm.nih.gov/pubmed/30836986
http://dx.doi.org/10.1186/s13395-019-0192-3
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