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A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging

BACKGROUND: To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation imaging based on deformable image registration (DIR) for external-beam partial b...

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Autores principales: Yu, Ting, Li, Jian Bin, Wang, Wei, Xu, Min, Zhang, Ying Jie, Shao, Qian, Liu, Xi Jun, Xu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402104/
https://www.ncbi.nlm.nih.gov/pubmed/30836970
http://dx.doi.org/10.1186/s13014-019-1244-x
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author Yu, Ting
Li, Jian Bin
Wang, Wei
Xu, Min
Zhang, Ying Jie
Shao, Qian
Liu, Xi Jun
Xu, Liang
author_facet Yu, Ting
Li, Jian Bin
Wang, Wei
Xu, Min
Zhang, Ying Jie
Shao, Qian
Liu, Xi Jun
Xu, Liang
author_sort Yu, Ting
collection PubMed
description BACKGROUND: To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation imaging based on deformable image registration (DIR) for external-beam partial breast irradiation (EB-PBI) after breast-conserving surgery (BCS). METHODS: Eighteen breast cancer patients suitable for EB-PBI were enrolled. Preoperative prone diagnostic MRI and postoperative prone CT scan sets for all the patients were acquired during free breathing. Target volumes and ipsilateral breast were all contoured by the same radiation oncologist. The gross tumor volume (GTV) delineated on the preoperative MRI images was denoted as the GTV(preMR) and the tumor bed (TB) delineated on the postoperative prone CT images was denoted as the GTV(postCT). The MIM software system was used to deformably register the MRI and CT images. RESULTS: When based on the coincidence of the compared target centers, there were statistically significant increases in the conformity index (CI) and degree of inclusion (DI) values for GTV(postCT)-GTV(preMR), GTV(postCT)-CTV(preMR + 10), CTV(postCT + 10)-GTV(preMR,) and CTV(postCT + 10)-CTV(preMR + 10) when compared with those based on the DIR of the thorax (Z = − 3.724, − 3.724, − 2.591, − 3.593, all P < 0.05; Z = -3.724, − 3.724, − 3.201, − 3.724, all P < 0.05, respectively). CONCLUSIONS: Although based on DIR, there was relatively poor spatial overlap between the preoperative prone diagnostic MRI images and the postoperative prone CT simulation images for either the whole breast or the target volumes. Therefore, it is unreasonable to use preoperative prone diagnostic MRI images to guide postoperative target delineation for EB-PBI.
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spelling pubmed-64021042019-03-14 A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging Yu, Ting Li, Jian Bin Wang, Wei Xu, Min Zhang, Ying Jie Shao, Qian Liu, Xi Jun Xu, Liang Radiat Oncol Research BACKGROUND: To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation imaging based on deformable image registration (DIR) for external-beam partial breast irradiation (EB-PBI) after breast-conserving surgery (BCS). METHODS: Eighteen breast cancer patients suitable for EB-PBI were enrolled. Preoperative prone diagnostic MRI and postoperative prone CT scan sets for all the patients were acquired during free breathing. Target volumes and ipsilateral breast were all contoured by the same radiation oncologist. The gross tumor volume (GTV) delineated on the preoperative MRI images was denoted as the GTV(preMR) and the tumor bed (TB) delineated on the postoperative prone CT images was denoted as the GTV(postCT). The MIM software system was used to deformably register the MRI and CT images. RESULTS: When based on the coincidence of the compared target centers, there were statistically significant increases in the conformity index (CI) and degree of inclusion (DI) values for GTV(postCT)-GTV(preMR), GTV(postCT)-CTV(preMR + 10), CTV(postCT + 10)-GTV(preMR,) and CTV(postCT + 10)-CTV(preMR + 10) when compared with those based on the DIR of the thorax (Z = − 3.724, − 3.724, − 2.591, − 3.593, all P < 0.05; Z = -3.724, − 3.724, − 3.201, − 3.724, all P < 0.05, respectively). CONCLUSIONS: Although based on DIR, there was relatively poor spatial overlap between the preoperative prone diagnostic MRI images and the postoperative prone CT simulation images for either the whole breast or the target volumes. Therefore, it is unreasonable to use preoperative prone diagnostic MRI images to guide postoperative target delineation for EB-PBI. BioMed Central 2019-03-05 /pmc/articles/PMC6402104/ /pubmed/30836970 http://dx.doi.org/10.1186/s13014-019-1244-x Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yu, Ting
Li, Jian Bin
Wang, Wei
Xu, Min
Zhang, Ying Jie
Shao, Qian
Liu, Xi Jun
Xu, Liang
A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging
title A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging
title_full A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging
title_fullStr A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging
title_full_unstemmed A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging
title_short A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging
title_sort comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402104/
https://www.ncbi.nlm.nih.gov/pubmed/30836970
http://dx.doi.org/10.1186/s13014-019-1244-x
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