Cargando…

A case of metastatic adrenocortical carcinoma

Adrenocortical carcinoma is a rare endocrine malignancy with poor prognosis. Adrenocortical carcinoma can be seen in familial syndromes such as multiple endocrine neoplasia 1(MEN-1), Li–Fraumeni syndrome, Beckwith–Wiedemann syndrome and Carney complex (Kjellman, M, Roshani, L, The, BT et al. Genotyp...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuthiah, N, Er, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402308/
https://www.ncbi.nlm.nih.gov/pubmed/30863550
http://dx.doi.org/10.1093/omcr/omz006
_version_ 1783400375111385088
author Kuthiah, N
Er, C
author_facet Kuthiah, N
Er, C
author_sort Kuthiah, N
collection PubMed
description Adrenocortical carcinoma is a rare endocrine malignancy with poor prognosis. Adrenocortical carcinoma can be seen in familial syndromes such as multiple endocrine neoplasia 1(MEN-1), Li–Fraumeni syndrome, Beckwith–Wiedemann syndrome and Carney complex (Kjellman, M, Roshani, L, The, BT et al. Genotyping of adrenocortical tumours: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16. J Clin Endocrinol Metab 1999;84:730-5). Treatment options for adrenocortical carcinoma are limited. We report a case of adrenocortical carcinoma in a 50-year-old lady who subsequently underwent adrenalectomy. She was started on mitotane as adjuvant therapy and chemotherapy after the metastatic lesions were found. Due to the rarity of the tumour, the understanding and experience of management modalities is limited. New treatment options may be available in the coming years to improve outcome. Early identification of tumour is key to increase the chances of progression free survival.
format Online
Article
Text
id pubmed-6402308
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-64023082019-03-12 A case of metastatic adrenocortical carcinoma Kuthiah, N Er, C Oxf Med Case Reports Case Report Adrenocortical carcinoma is a rare endocrine malignancy with poor prognosis. Adrenocortical carcinoma can be seen in familial syndromes such as multiple endocrine neoplasia 1(MEN-1), Li–Fraumeni syndrome, Beckwith–Wiedemann syndrome and Carney complex (Kjellman, M, Roshani, L, The, BT et al. Genotyping of adrenocortical tumours: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16. J Clin Endocrinol Metab 1999;84:730-5). Treatment options for adrenocortical carcinoma are limited. We report a case of adrenocortical carcinoma in a 50-year-old lady who subsequently underwent adrenalectomy. She was started on mitotane as adjuvant therapy and chemotherapy after the metastatic lesions were found. Due to the rarity of the tumour, the understanding and experience of management modalities is limited. New treatment options may be available in the coming years to improve outcome. Early identification of tumour is key to increase the chances of progression free survival. Oxford University Press 2019-02-27 /pmc/articles/PMC6402308/ /pubmed/30863550 http://dx.doi.org/10.1093/omcr/omz006 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Case Report
Kuthiah, N
Er, C
A case of metastatic adrenocortical carcinoma
title A case of metastatic adrenocortical carcinoma
title_full A case of metastatic adrenocortical carcinoma
title_fullStr A case of metastatic adrenocortical carcinoma
title_full_unstemmed A case of metastatic adrenocortical carcinoma
title_short A case of metastatic adrenocortical carcinoma
title_sort case of metastatic adrenocortical carcinoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402308/
https://www.ncbi.nlm.nih.gov/pubmed/30863550
http://dx.doi.org/10.1093/omcr/omz006
work_keys_str_mv AT kuthiahn acaseofmetastaticadrenocorticalcarcinoma
AT erc acaseofmetastaticadrenocorticalcarcinoma
AT kuthiahn caseofmetastaticadrenocorticalcarcinoma
AT erc caseofmetastaticadrenocorticalcarcinoma