Metformin Augments Panobinostat's Anti-Bladder Cancer Activity by Activating AMP-Activated Protein Kinase()()

Panobinostat, a histone deacetylase inhibitor, induces histone acetylation and acts against cancer but attenuates its anticancer activity by activating the mammalian target of rapamycin (mTOR) pathway. AMP-activated protein kinase (AMPK) is a cellular energy sensor that reportedly inhibits the mTOR...

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Detalles Bibliográficos
Autores principales: Okubo, Kazuki, Isono, Makoto, Asano, Takako, Sato, Akinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402380/
https://www.ncbi.nlm.nih.gov/pubmed/30849634
http://dx.doi.org/10.1016/j.tranon.2019.02.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402380/
https://www.ncbi.nlm.nih.gov/pubmed/30849634
http://dx.doi.org/10.1016/j.tranon.2019.02.001

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