Near‐Infrared Upconversion Luminescence and Bioimaging In Vivo Based on Quantum Dots

Recently, upconversion luminescence (UCL) has been widely applied in bioimaging due to its low autofluorescence and high contrast. However, a relatively high power density is still needed in conventional UCL bioimaging. In the present study, an ultralow power density light, as low as 0.06 mW cm(−2),...

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Detalles Bibliográficos
Autores principales: Qiu, Xiaochen, Zhu, Xingjun, Su, Xianlong, Xu, Ming, Yuan, Wei, Liu, Qingyun, Xue, Meng, Liu, Yawei, Feng, Wei, Li, Fuyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402406/
https://www.ncbi.nlm.nih.gov/pubmed/30886806
http://dx.doi.org/10.1002/advs.201801834
Descripción
Sumario:Recently, upconversion luminescence (UCL) has been widely applied in bioimaging due to its low autofluorescence and high contrast. However, a relatively high power density is still needed in conventional UCL bioimaging. In the present study, an ultralow power density light, as low as 0.06 mW cm(−2), is applied as an excitation source for UCL bioimaging with PbS/CdS/ZnS quantum dots (UCL‐QDs) as probes. The speculated UCL mechanism is a phonon‐assisted single‐photon process, and the relative quantum yield is up to 4.6%. As determined by continuous irradiation with a 980 nm laser, the UCL‐QDs show excellent photostability. Furthermore, UCL‐QDs‐based probe is applied in tumor, blood vessel, and lymph node bioimaging excited with an eye‐safe low‐power light‐emitting diode light in a nude mouse with few heat effects.

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