Management of low rectal gastrointestinal stromal tumor with neoadjuvant therapy and transanal excision: a rare case report and review of the literature

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. However, rectal GISTs represent only 5% of this category. We report a case of a rectal GIST treated with local excision after neoadjuvant therapy. CASE PRESENTATION: A 41-year-ol...

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Detalles Bibliográficos
Autores principales: Kosmidis, Christopher, Sapalidis, Konstantinos, Tsakalidis, Alexandros, Atmatzidis, Stefanos, Michalopoulos, Nikolaos, Koimtzis, Georgios, Karayannopoulou, Georgia, Lypiridou, Sofia, Varsamis, Nikolaos, Kouklakis, Georgios, Baka, Sofia, Zarogoulidis, Paul, Kesisoglou, Isaac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402437/
https://www.ncbi.nlm.nih.gov/pubmed/30881087
http://dx.doi.org/10.2147/IJGM.S193988
Descripción
Sumario:BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. However, rectal GISTs represent only 5% of this category. We report a case of a rectal GIST treated with local excision after neoadjuvant therapy. CASE PRESENTATION: A 41-year-old male patient presented with anal bleeding. Colonoscopy revealed a mass located 5 cm from the anal verge. Histological examination showed a GIST with immunohistochemical positivity for CD117 and CD34. Transanal local excision was performed after neoadjuvant therapy. CONCLUSION: Neoadjuvant immunotherapy for GISTs with unfavorable localization may facilitate local excision and avoid complications of more demanding operations.

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