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Preparation of sustained release apremilast-loaded PLGA nanoparticles: in vitro characterization and in vivo pharmacokinetic study in rats

BACKGROUND: Apremilast (APM) is a novel, orally administered small molecule drug approved for treatment of psoriasis or psoriatic arthritis. Due to its low solubility and permeability, it is classified as a class IV drug according to BCS classification. Dose titration is recommended during APM treat...

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Detalles Bibliográficos
Autores principales:	Anwer, Md Khalid, Mohammad, Muqtader, Ezzeldin, Essam, Fatima, Farhat, Alalaiwe, Ahmed, Iqbal, Muzaffar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402442/ https://www.ncbi.nlm.nih.gov/pubmed/30880967 http://dx.doi.org/10.2147/IJN.S195048

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