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The ubiquitin ligase KBTBD8 regulates PKM1 levels via Erk1/2 and Aurora A to ensure oocyte quality

Tight control of energy metabolism is essential for normal cell function and organism survival. PKM (pyruvate kinase, muscle) isoforms 1 and 2 originate from alternative splicing of PKM pre-mRNA. They are key enzymes in oxidative phosphorylation and aerobic glycolysis, respectively, and are essentia...

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Detalles Bibliográficos
Autores principales:	Li, Yan-Ru, Peng, Rui-Rui, Gao, Wen-Yi, Liu, Peng, Chen, Liang-Jian, Zhang, Xiao-Lan, Zhang, Na-Na, Wang, Yang, Du, Lei, Zhu, Feng-Yu, Wang, Li-Li, Li, Cong-Rong, Zeng, Wen-Tao, Li, Jian-Min, Hu, Fan, Zhang, Dong, Yang, Zhi-Xia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402520/ https://www.ncbi.nlm.nih.gov/pubmed/30786262 http://dx.doi.org/10.18632/aging.101802

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