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Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis
Visceral leishmaniasis (VL) causes significant mortality and morbidity in many parts of the world. There is an urgent need for the development of new, effective treatments for this disease. We describe the development of a novel anti-leishmanial drug-like chemical series based on a pyrazolopyrimidin...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402543/ https://www.ncbi.nlm.nih.gov/pubmed/30046105 http://dx.doi.org/10.1038/s41586-018-0356-z |