PDIP38/PolDIP2 controls the DNA damage tolerance pathways by increasing the relative usage of translesion DNA synthesis over template switching

Replicative DNA polymerases are frequently stalled at damaged template strands. Stalled replication forks are restored by the DNA damage tolerance (DDT) pathways, error-prone translesion DNA synthesis (TLS) to cope with excessive DNA damage, and error-free template switching (TS) by homologous DNA r...

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Detalles Bibliográficos
Autores principales: Tsuda, Masataka, Ogawa, Saki, Ooka, Masato, Kobayashi, Kaori, Hirota, Kouji, Wakasugi, Mitsuo, Matsunaga, Tsukasa, Sakuma, Tetsushi, Yamamoto, Takashi, Chikuma, Shunsuke, Sasanuma, Hiroyuki, Debatisse, Michelle, Doherty, Aidan J., Fuchs, Robert P., Takeda, Shunichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402704/
https://www.ncbi.nlm.nih.gov/pubmed/30840704
http://dx.doi.org/10.1371/journal.pone.0213383

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