A non-canonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis

Rheumatoid arthritis is characterized by progressive joint inflammation and affects ~1% of the human population. We noted single nucleotide polymorphisms (SNPs) in the apoptotic cell engulfment genes ELMO1, DOCK2, and RAC1 linked to rheumatoid arthritis. As ELMO1 promotes cytoskeletal reorganization...

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Detalles Bibliográficos
Autores principales: Arandjelovic, Sanja, Perry, Justin S.A., Lucas, Christopher D., Penberthy, Kristen K., Kim, Tae-Hyoun, Zhou, Ming, Rosen, Dorian A, Chuang, Tzu-Ying, Bettina, Alexandra M., Shankman, Laura S., Cohen, Amanda H., Gaultier, Alban, Conrads, Thomas P., Kim, Minsoo, Elliott, Michael R., Ravichandran, Kodi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402828/
https://www.ncbi.nlm.nih.gov/pubmed/30643265
http://dx.doi.org/10.1038/s41590-018-0293-x

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