A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair

Polo-like kinase 1 (Plk1) is a crucial regulator of cell cycle progression; but the mechanism of regulation of Plk1 activity is not well understood. We present evidence that Plk1 activity is controlled by a balanced methylation and phosphorylation switch. The methyltransferase G9a monomethylates Plk...

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Detalles Bibliográficos
Autores principales: Li, Weizhe, Wang, Hong-Yan, Zhao, Xiaolu, Duan, Hongguo, Cheng, Binghua, Liu, Yafei, Zhao, Mengjie, Shu, Wenjie, Mei, Yuchao, Wen, Zengqi, Tang, Mingliang, Guo, Lin, Li, Guohong, Chen, Qiang, Liu, Xiaoqi, Du, Hai-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402851/
https://www.ncbi.nlm.nih.gov/pubmed/30854428
http://dx.doi.org/10.1126/sciadv.aau7566

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