Simultaneous Presentation of Waldenström's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma

Waldenström's macroglobulinemia (WM) and multiple myeloma (MM) are two distinct forms of mature hematologic B-cell malignancies. A missense somatic mutation in MYD88 gene (MYD88L265P) has been found in hematologic B-cell malignancies. The simultaneous presentation of Waldenström's macroglo...

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Autores principales: Awada, Hassan, Kewan, Tariq, Covut, Fahrettin, Daw, Hamed, Haddad, Abdo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402863/
https://www.ncbi.nlm.nih.gov/pubmed/30868035
http://dx.doi.org/10.7759/cureus.3822
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author Awada, Hassan
Kewan, Tariq
Covut, Fahrettin
Daw, Hamed
Haddad, Abdo
author_facet Awada, Hassan
Kewan, Tariq
Covut, Fahrettin
Daw, Hamed
Haddad, Abdo
author_sort Awada, Hassan
collection PubMed
description Waldenström's macroglobulinemia (WM) and multiple myeloma (MM) are two distinct forms of mature hematologic B-cell malignancies. A missense somatic mutation in MYD88 gene (MYD88L265P) has been found in hematologic B-cell malignancies. The simultaneous presentation of Waldenström's macroglobulinemia and MYD88 mutation with multiple myeloma in the same patient is very rare and only a few cases have been reported in the literature.
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spelling pubmed-64028632019-03-13 Simultaneous Presentation of Waldenström's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma Awada, Hassan Kewan, Tariq Covut, Fahrettin Daw, Hamed Haddad, Abdo Cureus Genetics Waldenström's macroglobulinemia (WM) and multiple myeloma (MM) are two distinct forms of mature hematologic B-cell malignancies. A missense somatic mutation in MYD88 gene (MYD88L265P) has been found in hematologic B-cell malignancies. The simultaneous presentation of Waldenström's macroglobulinemia and MYD88 mutation with multiple myeloma in the same patient is very rare and only a few cases have been reported in the literature. Cureus 2019-01-03 /pmc/articles/PMC6402863/ /pubmed/30868035 http://dx.doi.org/10.7759/cureus.3822 Text en Copyright © 2019, Awada et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Awada, Hassan
Kewan, Tariq
Covut, Fahrettin
Daw, Hamed
Haddad, Abdo
Simultaneous Presentation of Waldenström's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma
title Simultaneous Presentation of Waldenström's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma
title_full Simultaneous Presentation of Waldenström's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma
title_fullStr Simultaneous Presentation of Waldenström's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma
title_full_unstemmed Simultaneous Presentation of Waldenström's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma
title_short Simultaneous Presentation of Waldenström's Macroglobulinemia and MYD88 Gene Mutation with Multiple Myeloma
title_sort simultaneous presentation of waldenström's macroglobulinemia and myd88 gene mutation with multiple myeloma
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402863/
https://www.ncbi.nlm.nih.gov/pubmed/30868035
http://dx.doi.org/10.7759/cureus.3822
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