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Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy
Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising class of immunotherapeutic that activate innate immunity to increase tumor immunogenicity. However, the efficacy of CDNs is limited by drug delivery barriers, including poor cellular targeting, rapid clearan...
Autores principales: | Shae, Daniel, Becker, Kyle W., Christov, Plamen, Yun, Dong Soo, Lytton-Jean, Abigail K.R., Sevimli, Sema, Ascano, Manuel, Kelley, Mark, Johnson, Douglas B., Balko, Justin M., Wilson, John T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402974/ https://www.ncbi.nlm.nih.gov/pubmed/30664751 http://dx.doi.org/10.1038/s41565-018-0342-5 |
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