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Efficient editing DNA regions with high sequence identity in actinomycetal genomes by a CRISPR-Cas9 system
Actinobacteria able to produce varieties of bioactive natural products have been long appreciated by the field of drug discovery and development. Recently, a few of CRISPR/Cas9 systems bearing different types of replicons (pSG5 and pIJ101) were developed to efficiently edit their genomes. Despite wi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
KeAi Publishing
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403111/ https://www.ncbi.nlm.nih.gov/pubmed/30891508 http://dx.doi.org/10.1016/j.synbio.2019.02.004 |