Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models

Receptor interacting protein kinase-1 and -3 (RIP1 and RIP3) are essential mediators of cell death processes and participate in inflammatory responses. Our group recently demonstrated that gene deletion of Rip3 or pharmacological inhibition of RIP1 attenuated pathogenesis of abdominal aortic aneurys...

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Detalles Bibliográficos
Autores principales: Zhou, Ting, Wang, Qiwei, Phan, Noel, Ren, Jun, Yang, Huan, Feldman, Conner C., Feltenberger, John B., Ye, Zhengqing, Wildman, Scott A., Tang, Weiping, Liu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403222/
https://www.ncbi.nlm.nih.gov/pubmed/30842407
http://dx.doi.org/10.1038/s41419-019-1468-6

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