Insights into the dynamic nature of the dsRNA-bound TLR3 complex

Toll-like receptor 3 (TLR3), an endosomal receptor crucial for immune responses upon viral invasion. The TLR3 ectodomain (ECD) is responsible for double-stranded RNA (dsRNA) recognition and mutational analysis suggested that TLR3 ECD C-terminal dimerization is essential for dsRNA binding. Moreover,...

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Detalles Bibliográficos
Autores principales: Gosu, Vijayakumar, Son, Seungwoo, Shin, Donghyun, Song, Ki-Duk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403236/
https://www.ncbi.nlm.nih.gov/pubmed/30842554
http://dx.doi.org/10.1038/s41598-019-39984-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403236/
https://www.ncbi.nlm.nih.gov/pubmed/30842554
http://dx.doi.org/10.1038/s41598-019-39984-8

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