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ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield
The efficacy of Fluorouracil (FU) in the treatment of colorectal cancer (CRC) is greatly limited by drug resistance. Autophagy has been implicated in chemoresistance, but the role of selective autophagic degradation in regulating chemoresistance remains unknown. In this study, we revealed a critical...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403256/ https://www.ncbi.nlm.nih.gov/pubmed/30842415 http://dx.doi.org/10.1038/s41467-019-08902-x |