ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

The efficacy of Fluorouracil (FU) in the treatment of colorectal cancer (CRC) is greatly limited by drug resistance. Autophagy has been implicated in chemoresistance, but the role of selective autophagic degradation in regulating chemoresistance remains unknown. In this study, we revealed a critical...

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Detalles Bibliográficos
Autores principales: Ou, Juanjuan, Peng, Yuan, Yang, Weiwen, Zhang, Yue, Hao, Jie, Li, Fu, Chen, Yanrong, Zhao, Yang, Xie, Xiong, Wu, Shuang, Zha, Lin, Luo, Xi, Xie, Ganfeng, Wang, Liting, Sun, Wei, Zhou, Qi, Li, Jianjun, Liang, Houjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403256/
https://www.ncbi.nlm.nih.gov/pubmed/30842415
http://dx.doi.org/10.1038/s41467-019-08902-x

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