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Hybrid approach to sieve out natural compounds against dual targets in Alzheimer’s Disease
Excess Aβ production by the key protease BACE1, results in Aβ aggregation, forming amyloid plaques, all of which contribute to the pathogenesis of Alzheimer’s disease. Besides the multi-factorial nature of the disease, the diversity in the size and shape of known ligands that bind to the active site...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403309/ https://www.ncbi.nlm.nih.gov/pubmed/30842555 http://dx.doi.org/10.1038/s41598-019-40271-9 |