Cargando…

Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide

Microbial resistance against clinical used antibiotics is on the rise. Accordingly, there is a high demand for new innovative antimicrobial strategies. The host-defense peptide human beta-defensin 1 (hBD-1) is produced continuously by epithelial cells and exhibits compelling antimicrobial activity a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wendler, Judith, Schroeder, Bjoern O., Ehmann, Dirk, Koeninger, Louis, Mailänder-Sánchez, Daniela, Lemberg, Christina, Wanner, Stephanie, Schaller, Martin, Stange, Eduard F., Malek, Nisar P., Weidenmaier, Christopher, LeibundGut-Landmann, Salomé, Wehkamp, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403363/ https://www.ncbi.nlm.nih.gov/pubmed/30842543 http://dx.doi.org/10.1038/s41598-019-40216-2

Ejemplares similares

Fragmentation of Human Neutrophil α-Defensin 4 to Combat Multidrug Resistant Bacteria
por: Ehmann, Dirk, et al.
Publicado: (2020)

Tissue-Resident Memory T Cells in Antifungal Immunity
por: LeibundGut-Landmann, Salomé
Publicado: (2021)

S9.5c Malassezia-host interactions and the Il-23/17 axis
por: LeibundGut-Landmann, Salomé
Publicado: (2022)

Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments
por: Ehmann, D., et al.
Publicado: (2019)

Innate Lymphoid Cells: New Players in IL-17-Mediated Antifungal Immunity
por: Gladiator, André, et al.
Publicado: (2013)

Interleukin 17-Mediated Host Defense against Candida albicans
por: Sparber, Florian, et al.
Publicado: (2015)

Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans
por: Braunsdorf, Christina, et al.
Publicado: (2018)

Host Responses to Malassezia spp. in the Mammalian Skin
por: Sparber, Florian, et al.
Publicado: (2017)

Interleukin-17 in Antifungal Immunity
por: Sparber, Florian, et al.
Publicado: (2019)

Immunosurveillance of Candida albicans commensalism by the adaptive immune system
por: Swidergall, Marc, et al.
Publicado: (2022)

New insights into immunity to skin fungi shape our understanding of health and disease
por: Ruchti, Fiorella, et al.
Publicado: (2022)

Editorial: Malassezia: A Skin Commensal Yeast Impacting Both Health and Disease
por: LeibundGut-Landmann, Salomé, et al.
Publicado: (2021)

Tissue-resident memory Th17 cells maintain stable fungal commensalism in the oral mucosa
por: Kirchner, Florian R., et al.
Publicado: (2020)

Candida albicans-Induced NETosis Is Independent of Peptidylarginine Deiminase 4
por: Guiducci, Eva, et al.
Publicado: (2018)

Host Immunity to Malassezia in Health and Disease
por: Sparber, Florian, et al.
Publicado: (2020)

IL-23 supports host defense against systemic Candida albicans infection by ensuring myeloid cell survival
por: Nur, Selim, et al.
Publicado: (2019)

Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide
por: Schroeder, B O, et al.
Publicado: (2015)

S6.3d Candida albicans commensalism in the oral mucosa is favored by limited virulence and metabolic adaptation
por: Gut-Landmann, Salomé Leibund
Publicado: (2022)

Dendritic cell quiescence during systemic inflammation driven by LPS stimulation of radioresistant cells in vivo
por: Nolte, Martijn A., et al.
Publicado: (2007)

A Novel Mycovirus Evokes Transcriptional Rewiring in the Fungus Malassezia and Stimulates Beta Interferon Production in Macrophages
por: Applen Clancey, Shelly, et al.
Publicado: (2020)

Curbing gastrointestinal infections by defensin fragment modifications without harming commensal microbiota
por: Koeninger, Louis, et al.
Publicado: (2021)

Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis
por: Koeninger, Louis, et al.
Publicado: (2020)

IL-1 Coordinates the Neutrophil Response to C. albicans in the Oral Mucosa
por: Altmeier, Simon, et al.
Publicado: (2016)

Persistence of Candida albicans in the Oral Mucosa Induces a Curbed Inflammatory Host Response That Is Independent of Immunosuppression
por: Kirchner, Florian R., et al.
Publicado: (2019)

β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor
por: Klag, Thomas, et al.
Publicado: (2018)

Role of NS1 and TLR3 in Pathogenesis and Immunity of WNV
por: Patel, Sameera, et al.
Publicado: (2019)

Innate immunity includes defensins
por: Jäger, Simon, et al.
Publicado: (2012)

DC activated via dectin-1 convert Treg into IL-17 producers
por: Osorio, Fabiola, et al.
Publicado: (2008)

Antigen-Specific Th17 Cells Are Primed by Distinct and Complementary Dendritic Cell Subsets in Oropharyngeal Candidiasis
por: Trautwein-Weidner, Kerstin, et al.
Publicado: (2015)

Rapid and Serial Quantification of Adhesion Forces of Yeast and Mammalian Cells
por: Potthoff, Eva, et al.
Publicado: (2012)

Langerin(+) DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection
por: Sparber, Florian, et al.
Publicado: (2018)

Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action
por: Raschig, Judith, et al.
Publicado: (2017)

Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation
por: Lemberg, Christina, et al.
Publicado: (2022)

Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection
por: Whitney, Paul G., et al.
Publicado: (2014)

Correction: Syk Signaling in Dendritic Cells Orchestrates Innate Resistance to Systemic Fungal Infection
por: Whitney, Paul G., et al.
Publicado: (2018)

Human α-Defensin 5(1–9) and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet
por: Filipe Rosa, Louisa, et al.
Publicado: (2023)

Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin
por: Jaeger, S U, et al.
Publicado: (2013)

Lymph node stromal cells acquire peptide–MHCII complexes from dendritic cells and induce antigen-specific CD4(+) T cell tolerance
por: Dubrot, Juan, et al.
Publicado: (2014)

An NK Cell Perforin Response Elicited via IL-18 Controls Mucosal Inflammation Kinetics during Salmonella Gut Infection
por: Müller, Anna A., et al.
Publicado: (2016)

Probiotic E. coli treatment mediates antimicrobial human β-defensin synthesis and fecal excretion in humans
por: Möndel, M, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_52sngnei58i5viuc3unjo0va2l