Cargando…

Age-related gene and miRNA expression changes in airways of healthy individuals

Knowledge on age-related miRNA changes in healthy individuals and their interaction with mRNAs is lacking. We studied age-related mRNA and miRNA expression changes and their interactions in normal airways. RNA and small RNA sequencing was performed on bronchial biopsies of 86 healthy individuals (ag...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ong, J., Woldhuis, R. R., Boudewijn, I. M., van den Berg, A., Kluiver, J., Kok, K., Terpstra, M. M., Guryev, V., de Vries, M., Vermeulen, C. J., Timens, W., van den Berge, M., Brandsma, C. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403379/ https://www.ncbi.nlm.nih.gov/pubmed/30842487 http://dx.doi.org/10.1038/s41598-019-39873-0

Ejemplares similares

Marked TGF-β-regulated miRNA expression changes in both COPD and control lung fibroblasts
por: Ong, J., et al.
Publicado: (2019)

Current Smoking is Associated with Decreased Expression of miR-335-5p in Parenchymal Lung Fibroblasts
por: Ong, Jennie, et al.
Publicado: (2019)

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins
por: Woldhuis, Roy R, et al.
Publicado: (2021)

The relation between age and airway epithelial barrier function
por: de Vries, M., et al.
Publicado: (2022)

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?
por: Brandsma, Corry-Anke, et al.
Publicado: (2017)

Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts
por: Ong, Jennie, et al.
Publicado: (2017)

Differential miRNA Expression Profiles in Cumulus and Mural Granulosa Cells from Human Pre-ovulatory Follicles
por: Andrei, Daniela, et al.
Publicado: (2019)

High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD
por: van Nijnatten, Jos, et al.
Publicado: (2022)

Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium
por: Pouwels, Simon D., et al.
Publicado: (2023)

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
por: Brandsma, Corry‐Anke, et al.
Publicado: (2019)

Mutations in EMT-Related Genes in ALK Positive Crizotinib Resistant Non-Small Cell Lung Cancers
por: Wei, Jiacong, et al.
Publicado: (2018)

Comprehensive analysis of miRNA expression in T-cell subsets of rheumatoid arthritis patients reveals defined signatures of naive and memory Tregs
por: Smigielska-Czepiel, K, et al.
Publicado: (2014)

Genomic Aberrations in Crizotinib Resistant Lung Adenocarcinoma Samples Identified by Transcriptome Sequencing
por: Saber, Ali, et al.
Publicado: (2016)

Integrated proteogenomic approach identifying a protein signature of COPD and a new splice variant of SORBS1
por: Brandsma, Corry-Anke, et al.
Publicado: (2020)

Budesonide and fluticasone propionate differentially affect the airway epithelial barrier
por: Heijink, I. H., et al.
Publicado: (2016)

Genetic regulation of gene expression of MIF family members in lung tissue
por: Florez-Sampedro, Laura, et al.
Publicado: (2020)

Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways
por: Aliee, H., et al.
Publicado: (2020)

Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
por: Ditz, Benedikt, et al.
Publicado: (2021)

A bronchial gene signature specific for severe COPD that is retained in the nose
por: van Nijnatten, Jos, et al.
Publicado: (2023)

Nasal gene expression differentiates COPD from controls and overlaps bronchial gene expression
por: Boudewijn, Ilse M., et al.
Publicado: (2017)

Involvement of MicroRNAs in the Aging-Related Decline of CD28 Expression by Human T Cells
por: Teteloshvili, Nato, et al.
Publicado: (2018)

Overall survival in EGFR mutated non-small-cell lung cancer patients treated with afatinib after EGFR TKI and resistant mechanisms upon disease progression
por: van der Wekken, A. J., et al.
Publicado: (2017)

Airway wall splice quantitative trait locus analysis reveals novel downstream mechanisms for known asthma single-nucleotide polymorphisms
por: Kole, Tessa M., et al.
Publicado: (2023)

The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth
por: Niu, Fubiao, et al.
Publicado: (2020)

Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD
por: Song, J., et al.
Publicado: (2017)

Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling
por: Wang, Junfei, et al.
Publicado: (2018)

Cigarette smoke exposure decreases CFLAR expression in the bronchial epithelium, augmenting susceptibility for lung epithelial cell death and DAMP release
por: Faiz, Alen, et al.
Publicado: (2018)

An All-In-One Transcriptome-Based Assay to Identify Therapy-Guiding Genomic Aberrations in Nonsmall Cell Lung Cancer Patients
por: Wei, Jiacong, et al.
Publicado: (2020)

AGER expression and alternative splicing in bronchial biopsies of smokers and never smokers
por: Faiz, Alen, et al.
Publicado: (2019)

MicroRNA profiling of human primary macrophages exposed to dengue virus identifies miRNA-3614-5p as antiviral and regulator of ADAR1 expression
por: Diosa-Toro, Mayra, et al.
Publicado: (2017)

MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast–Epithelium Crosstalk
por: Tasena, Hataitip, et al.
Publicado: (2022)

Finally More Direct Evidence That Impulse Oscillometry Measures Small Airway Disease
por: van den Berge, Maarten, et al.
Publicado: (2019)

Assessing small airways dysfunction in asthma, asthma remission and healthy controls using particles in exhaled air
por: Carpaij, Orestes A., et al.
Publicado: (2019)

Age-Associated Differences in MiRNA Signatures Are Restricted to CD45RO Negative T Cells and Are Associated with Changes in the Cellular Composition, Activation and Cellular Ageing
por: Teteloshvili, Nato, et al.
Publicado: (2015)

Smooth-muscle-derived WNT5A augments allergen-induced airway remodelling and Th2 type inflammation
por: Koopmans, Tim, et al.
Publicado: (2020)

Intricate crosstalk between MYC and non‐coding RNAs regulates hallmarks of cancer
por: Swier, Lotteke J. Y. M., et al.
Publicado: (2018)

Observation of Nociceptive Processing: Effect of Intra-Epidermal Electric Stimulus Properties on Detection Probability and Evoked Potentials
por: van den Berg, Boudewijn, et al.
Publicado: (2021)

Serum periostin does not reflect type 2-driven inflammation in COPD
por: Carpaij, O. A., et al.
Publicado: (2018)

Associations of AMP and adenosine induced dyspnea sensation to large and small airways dysfunction in asthma
por: Cox, Claire A., et al.
Publicado: (2019)

Identifying a nasal gene expression signature associated with hyperinflation and treatment response in severe COPD
por: Faiz, Alen, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_u88f1de29369au3ki0hph19vbv