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Global computational mutagenesis of domain structures associated with inherited eye disease
Multidomain proteins account for 70% of the eukaryotic proteome. In genetic disease, multidomain proteins are often affected by numerous mutations, but the effects of these mutations on protein stability and their roles in genetic disease are not well understood. Here, we analyzed protein globular d...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403380/ https://www.ncbi.nlm.nih.gov/pubmed/30842450 http://dx.doi.org/10.1038/s41598-019-39905-9 |