Vector uncoating limits adeno-associated viral vector-mediated transduction of human dendritic cells and vector immunogenicity

AAV vectors poorly transduce Dendritic cells (DC), a feature invoked to explain AAV’s low immunogenicity. However, the reason for this non-permissiveness remained elusive. Here, we performed an in-depth analysis using human monocyte-derived immature DC (iDC) as model. iDC internalized AAV vectors of...

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Detalles Bibliográficos
Autores principales: Rossi, Axel, Dupaty, Léa, Aillot, Ludovic, Zhang, Liang, Gallien, Célia, Hallek, Michael, Odenthal, Margarete, Adriouch, Sahil, Salvetti, Anna, Büning, Hildegard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403382/
https://www.ncbi.nlm.nih.gov/pubmed/30842485
http://dx.doi.org/10.1038/s41598-019-40071-1

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