Scaling and correlation properties of RR and QT intervals at the cellular level

We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)...

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Autores principales: Kim, Jiyeong, Shah, Disheet, Potapov, Ilya, Latukka, Joonas, Aalto-Setälä, Katriina, Räsänen, Esa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403385/
https://www.ncbi.nlm.nih.gov/pubmed/30842620
http://dx.doi.org/10.1038/s41598-019-40247-9
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author Kim, Jiyeong
Shah, Disheet
Potapov, Ilya
Latukka, Joonas
Aalto-Setälä, Katriina
Räsänen, Esa
author_facet Kim, Jiyeong
Shah, Disheet
Potapov, Ilya
Latukka, Joonas
Aalto-Setälä, Katriina
Räsänen, Esa
author_sort Kim, Jiyeong
collection PubMed
description We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our detrended fluctuation analysis and Poincaré plots reveal remarkable similarities between the ECG and hiPSC-CM data. In particular, no statistically significant difference was found in the short- and long-term scaling exponents α(1) and α(2) of RR and QT intervals and their cellular equivalences. Previously unknown scaling properties of FPDs of hiPSC-CM aggregates reveal that the increasing scaling exponent of QT intervals as a function of the time scale, is an intrinsic feature at the cellular level.
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spelling pubmed-64033852019-03-11 Scaling and correlation properties of RR and QT intervals at the cellular level Kim, Jiyeong Shah, Disheet Potapov, Ilya Latukka, Joonas Aalto-Setälä, Katriina Räsänen, Esa Sci Rep Article We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our detrended fluctuation analysis and Poincaré plots reveal remarkable similarities between the ECG and hiPSC-CM data. In particular, no statistically significant difference was found in the short- and long-term scaling exponents α(1) and α(2) of RR and QT intervals and their cellular equivalences. Previously unknown scaling properties of FPDs of hiPSC-CM aggregates reveal that the increasing scaling exponent of QT intervals as a function of the time scale, is an intrinsic feature at the cellular level. Nature Publishing Group UK 2019-03-06 /pmc/articles/PMC6403385/ /pubmed/30842620 http://dx.doi.org/10.1038/s41598-019-40247-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Jiyeong
Shah, Disheet
Potapov, Ilya
Latukka, Joonas
Aalto-Setälä, Katriina
Räsänen, Esa
Scaling and correlation properties of RR and QT intervals at the cellular level
title Scaling and correlation properties of RR and QT intervals at the cellular level
title_full Scaling and correlation properties of RR and QT intervals at the cellular level
title_fullStr Scaling and correlation properties of RR and QT intervals at the cellular level
title_full_unstemmed Scaling and correlation properties of RR and QT intervals at the cellular level
title_short Scaling and correlation properties of RR and QT intervals at the cellular level
title_sort scaling and correlation properties of rr and qt intervals at the cellular level
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403385/
https://www.ncbi.nlm.nih.gov/pubmed/30842620
http://dx.doi.org/10.1038/s41598-019-40247-9
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