Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report

• NMDA-receptor subunit expression of NR2A and NR2B is downregulated in heterotopias. • Glutamatergic transmission in the hyperexcitability of nodular heterotopias is implicated. • Mechanisms in PVNH to establish etiology specific therapies are still to be defined.

Detalles Bibliográficos
Autores principales: Kiyose, Makoto, Wagner, Marlies, Männer, Annika, Reitz, Sarah C., Klein, Karl Martin, Strzelczyk, Adam, Bauer, Sebastian, Rosenow, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403409/
https://www.ncbi.nlm.nih.gov/pubmed/30891403
http://dx.doi.org/10.1016/j.ebcr.2019.01.009
Descripción
Sumario:• NMDA-receptor subunit expression of NR2A and NR2B is downregulated in heterotopias. • Glutamatergic transmission in the hyperexcitability of nodular heterotopias is implicated. • Mechanisms in PVNH to establish etiology specific therapies are still to be defined.

Ejemplares similares