Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report

• NMDA-receptor subunit expression of NR2A and NR2B is downregulated in heterotopias. • Glutamatergic transmission in the hyperexcitability of nodular heterotopias is implicated. • Mechanisms in PVNH to establish etiology specific therapies are still to be defined.

Detalles Bibliográficos
Autores principales: Kiyose, Makoto, Wagner, Marlies, Männer, Annika, Reitz, Sarah C., Klein, Karl Martin, Strzelczyk, Adam, Bauer, Sebastian, Rosenow, Felix
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403409/
https://www.ncbi.nlm.nih.gov/pubmed/30891403
http://dx.doi.org/10.1016/j.ebcr.2019.01.009
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author Kiyose, Makoto
Wagner, Marlies
Männer, Annika
Reitz, Sarah C.
Klein, Karl Martin
Strzelczyk, Adam
Bauer, Sebastian
Rosenow, Felix
author_facet Kiyose, Makoto
Wagner, Marlies
Männer, Annika
Reitz, Sarah C.
Klein, Karl Martin
Strzelczyk, Adam
Bauer, Sebastian
Rosenow, Felix
author_sort Kiyose, Makoto
collection PubMed
description • NMDA-receptor subunit expression of NR2A and NR2B is downregulated in heterotopias. • Glutamatergic transmission in the hyperexcitability of nodular heterotopias is implicated. • Mechanisms in PVNH to establish etiology specific therapies are still to be defined.
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spelling pubmed-64034092019-03-19 Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report Kiyose, Makoto Wagner, Marlies Männer, Annika Reitz, Sarah C. Klein, Karl Martin Strzelczyk, Adam Bauer, Sebastian Rosenow, Felix Epilepsy Behav Case Rep Article • NMDA-receptor subunit expression of NR2A and NR2B is downregulated in heterotopias. • Glutamatergic transmission in the hyperexcitability of nodular heterotopias is implicated. • Mechanisms in PVNH to establish etiology specific therapies are still to be defined. Elsevier 2019-02-13 /pmc/articles/PMC6403409/ /pubmed/30891403 http://dx.doi.org/10.1016/j.ebcr.2019.01.009 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Kiyose, Makoto
Wagner, Marlies
Männer, Annika
Reitz, Sarah C.
Klein, Karl Martin
Strzelczyk, Adam
Bauer, Sebastian
Rosenow, Felix
Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report
title Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report
title_full Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report
title_fullStr Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report
title_full_unstemmed Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report
title_short Long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: A case report
title_sort long term seizure freedom on perampanel in highly drug-resistant epilepsy caused by bilateral periventricular nodular heterotopia: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403409/
https://www.ncbi.nlm.nih.gov/pubmed/30891403
http://dx.doi.org/10.1016/j.ebcr.2019.01.009
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