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Endogenously Expressed Antigens Bind Mammalian RNA via Cationic Domains that Enhance Priming of Effector CD8 T Cells by DNA Vaccination

Hepatitis B virus (HBV) core (HBV-C) antigens with homologous or heterologous HIV-tat48-57-like (HBV-C149tat) cationic domains non-specifically bind cellular RNA in vector-transfected cells. Here, we investigated whether RNA-binding to cationic domains influences the immunogenicity of endogenously e...

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Detalles Bibliográficos
Autores principales:	Krieger, Jana, Riedl, Petra, Stifter, Katja, Roman-Sosa, Gleyder, Seufferlein, Thomas, Wagner, Martin, Schirmbeck, Reinhold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403493/ https://www.ncbi.nlm.nih.gov/pubmed/30713086 http://dx.doi.org/10.1016/j.ymthe.2019.01.011

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