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New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents

This work presents three new experimental methods for studying molecular imprinting. The electric conductivity measurements of the pre-polymerization mixture of amine templates in an aprotic solvent provide evidence of ionic dissociation of the pre-polymerization complexes. The displacement measurem...

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Autores principales: Nagy-Szakolczai, Anett, Dorkó, Zsanett, Tóth, Blanka, Horvai, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403568/
https://www.ncbi.nlm.nih.gov/pubmed/30960940
http://dx.doi.org/10.3390/polym10091015
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author Nagy-Szakolczai, Anett
Dorkó, Zsanett
Tóth, Blanka
Horvai, George
author_facet Nagy-Szakolczai, Anett
Dorkó, Zsanett
Tóth, Blanka
Horvai, George
author_sort Nagy-Szakolczai, Anett
collection PubMed
description This work presents three new experimental methods for studying molecular imprinting. The electric conductivity measurements of the pre-polymerization mixture of amine templates in an aprotic solvent provide evidence of ionic dissociation of the pre-polymerization complexes. The displacement measurement of the template propranolol from its molecularly imprinted polymer (MIP) using a quaternary ammonium ion in toluene, shows that this MIP behaves as an ion exchanger even in a non-polar solvent. The same experiment also shows that template binding to the MIP from toluene involves ionic interaction. The third experimental method introduced here serves to study the models of template binding on MIPs. To this end the binding isotherm of propranolol (PR) has been measured on a polymer mixture consisting of non-imprinted control polymer (NIP) and a stronger binding acidic polymer, respectively. All three methods are suitable for studying several other imprinting systems.
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spelling pubmed-64035682019-04-02 New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents Nagy-Szakolczai, Anett Dorkó, Zsanett Tóth, Blanka Horvai, George Polymers (Basel) Article This work presents three new experimental methods for studying molecular imprinting. The electric conductivity measurements of the pre-polymerization mixture of amine templates in an aprotic solvent provide evidence of ionic dissociation of the pre-polymerization complexes. The displacement measurement of the template propranolol from its molecularly imprinted polymer (MIP) using a quaternary ammonium ion in toluene, shows that this MIP behaves as an ion exchanger even in a non-polar solvent. The same experiment also shows that template binding to the MIP from toluene involves ionic interaction. The third experimental method introduced here serves to study the models of template binding on MIPs. To this end the binding isotherm of propranolol (PR) has been measured on a polymer mixture consisting of non-imprinted control polymer (NIP) and a stronger binding acidic polymer, respectively. All three methods are suitable for studying several other imprinting systems. MDPI 2018-09-12 /pmc/articles/PMC6403568/ /pubmed/30960940 http://dx.doi.org/10.3390/polym10091015 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nagy-Szakolczai, Anett
Dorkó, Zsanett
Tóth, Blanka
Horvai, George
New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents
title New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents
title_full New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents
title_fullStr New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents
title_full_unstemmed New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents
title_short New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents
title_sort new methods to study the behavior of molecularly imprinted polymers in aprotic solvents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403568/
https://www.ncbi.nlm.nih.gov/pubmed/30960940
http://dx.doi.org/10.3390/polym10091015
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