Cargando…
New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents
This work presents three new experimental methods for studying molecular imprinting. The electric conductivity measurements of the pre-polymerization mixture of amine templates in an aprotic solvent provide evidence of ionic dissociation of the pre-polymerization complexes. The displacement measurem...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403568/ https://www.ncbi.nlm.nih.gov/pubmed/30960940 http://dx.doi.org/10.3390/polym10091015 |
_version_ | 1783400639691227136 |
---|---|
author | Nagy-Szakolczai, Anett Dorkó, Zsanett Tóth, Blanka Horvai, George |
author_facet | Nagy-Szakolczai, Anett Dorkó, Zsanett Tóth, Blanka Horvai, George |
author_sort | Nagy-Szakolczai, Anett |
collection | PubMed |
description | This work presents three new experimental methods for studying molecular imprinting. The electric conductivity measurements of the pre-polymerization mixture of amine templates in an aprotic solvent provide evidence of ionic dissociation of the pre-polymerization complexes. The displacement measurement of the template propranolol from its molecularly imprinted polymer (MIP) using a quaternary ammonium ion in toluene, shows that this MIP behaves as an ion exchanger even in a non-polar solvent. The same experiment also shows that template binding to the MIP from toluene involves ionic interaction. The third experimental method introduced here serves to study the models of template binding on MIPs. To this end the binding isotherm of propranolol (PR) has been measured on a polymer mixture consisting of non-imprinted control polymer (NIP) and a stronger binding acidic polymer, respectively. All three methods are suitable for studying several other imprinting systems. |
format | Online Article Text |
id | pubmed-6403568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64035682019-04-02 New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents Nagy-Szakolczai, Anett Dorkó, Zsanett Tóth, Blanka Horvai, George Polymers (Basel) Article This work presents three new experimental methods for studying molecular imprinting. The electric conductivity measurements of the pre-polymerization mixture of amine templates in an aprotic solvent provide evidence of ionic dissociation of the pre-polymerization complexes. The displacement measurement of the template propranolol from its molecularly imprinted polymer (MIP) using a quaternary ammonium ion in toluene, shows that this MIP behaves as an ion exchanger even in a non-polar solvent. The same experiment also shows that template binding to the MIP from toluene involves ionic interaction. The third experimental method introduced here serves to study the models of template binding on MIPs. To this end the binding isotherm of propranolol (PR) has been measured on a polymer mixture consisting of non-imprinted control polymer (NIP) and a stronger binding acidic polymer, respectively. All three methods are suitable for studying several other imprinting systems. MDPI 2018-09-12 /pmc/articles/PMC6403568/ /pubmed/30960940 http://dx.doi.org/10.3390/polym10091015 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nagy-Szakolczai, Anett Dorkó, Zsanett Tóth, Blanka Horvai, George New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents |
title | New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents |
title_full | New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents |
title_fullStr | New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents |
title_full_unstemmed | New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents |
title_short | New Methods to Study the Behavior of Molecularly Imprinted Polymers in Aprotic Solvents |
title_sort | new methods to study the behavior of molecularly imprinted polymers in aprotic solvents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403568/ https://www.ncbi.nlm.nih.gov/pubmed/30960940 http://dx.doi.org/10.3390/polym10091015 |
work_keys_str_mv | AT nagyszakolczaianett newmethodstostudythebehaviorofmolecularlyimprintedpolymersinaproticsolvents AT dorkozsanett newmethodstostudythebehaviorofmolecularlyimprintedpolymersinaproticsolvents AT tothblanka newmethodstostudythebehaviorofmolecularlyimprintedpolymersinaproticsolvents AT horvaigeorge newmethodstostudythebehaviorofmolecularlyimprintedpolymersinaproticsolvents |