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Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration

The effective treatment of chronic wounds constitutes one of the most common worldwide healthcare problem due to the presence of high levels of proteases, free radicals and exudates in the wound, which constantly activate the inflammatory system, avoiding tissue regeneration. In this study, we descr...

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Detalles Bibliográficos
Autores principales: Puertas-Bartolomé, María, Vázquez-Lasa, Blanca, San Román, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403640/
https://www.ncbi.nlm.nih.gov/pubmed/30960693
http://dx.doi.org/10.3390/polym10070768
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author Puertas-Bartolomé, María
Vázquez-Lasa, Blanca
San Román, Julio
author_facet Puertas-Bartolomé, María
Vázquez-Lasa, Blanca
San Román, Julio
author_sort Puertas-Bartolomé, María
collection PubMed
description The effective treatment of chronic wounds constitutes one of the most common worldwide healthcare problem due to the presence of high levels of proteases, free radicals and exudates in the wound, which constantly activate the inflammatory system, avoiding tissue regeneration. In this study, we describe a multifunctional bioactive and resorbable membrane with in-built antioxidant agent catechol for the continuous quenching of free radicals as well as to control inflammatory response, helping to promote the wound-healing process. This natural polyphenol (catechol) is the key molecule responsible for the mechanism of adhesion of mussels providing also the functionalized polymer with bioadhesion in the moist environment of the human body. To reach that goal, synthesized statistical copolymers of N-vinylcaprolactam (V) and 2-hydroxyethyl methacrylate (H) have been conjugated with catechol bearing hydrocaffeic acid (HCA) molecules with high yields. The system has demonstrated good biocompatibility, a sustained antioxidant response, an anti-inflammatory effect, an ultraviolet (UV) screen, and bioadhesion to porcine skin, all of these been key features in the wound-healing process. Therefore, these novel mussel-inspired materials have an enormous potential for application and can act very positively, favoring and promoting the healing effect in chronic wounds.
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spelling pubmed-64036402019-04-02 Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration Puertas-Bartolomé, María Vázquez-Lasa, Blanca San Román, Julio Polymers (Basel) Article The effective treatment of chronic wounds constitutes one of the most common worldwide healthcare problem due to the presence of high levels of proteases, free radicals and exudates in the wound, which constantly activate the inflammatory system, avoiding tissue regeneration. In this study, we describe a multifunctional bioactive and resorbable membrane with in-built antioxidant agent catechol for the continuous quenching of free radicals as well as to control inflammatory response, helping to promote the wound-healing process. This natural polyphenol (catechol) is the key molecule responsible for the mechanism of adhesion of mussels providing also the functionalized polymer with bioadhesion in the moist environment of the human body. To reach that goal, synthesized statistical copolymers of N-vinylcaprolactam (V) and 2-hydroxyethyl methacrylate (H) have been conjugated with catechol bearing hydrocaffeic acid (HCA) molecules with high yields. The system has demonstrated good biocompatibility, a sustained antioxidant response, an anti-inflammatory effect, an ultraviolet (UV) screen, and bioadhesion to porcine skin, all of these been key features in the wound-healing process. Therefore, these novel mussel-inspired materials have an enormous potential for application and can act very positively, favoring and promoting the healing effect in chronic wounds. MDPI 2018-07-13 /pmc/articles/PMC6403640/ /pubmed/30960693 http://dx.doi.org/10.3390/polym10070768 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Puertas-Bartolomé, María
Vázquez-Lasa, Blanca
San Román, Julio
Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
title Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
title_full Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
title_fullStr Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
title_full_unstemmed Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
title_short Bioactive and Bioadhesive Catechol Conjugated Polymers for Tissue Regeneration
title_sort bioactive and bioadhesive catechol conjugated polymers for tissue regeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403640/
https://www.ncbi.nlm.nih.gov/pubmed/30960693
http://dx.doi.org/10.3390/polym10070768
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