Cargando…

Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers

Engineering of multifunctional drug nanocarriers combining stability and good release properties remains a great challenge. In this work, natural polymers κ-carrageenan (κ-CAR) and chitosan (CS) were deposited onto olive oil nanoemulsion droplets (NE) via layer-by-layer (LbL) self-assembly to study...

Descripción completa

Detalles Bibliográficos
Autores principales: Rochín-Wong, Sarai, Rosas-Durazo, Aarón, Zavala-Rivera, Paul, Maldonado, Amir, Martínez-Barbosa, María Elisa, Vélaz, Itziar, Tánori, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403737/
https://www.ncbi.nlm.nih.gov/pubmed/30960685
http://dx.doi.org/10.3390/polym10070760
_version_ 1783400688858955776
author Rochín-Wong, Sarai
Rosas-Durazo, Aarón
Zavala-Rivera, Paul
Maldonado, Amir
Martínez-Barbosa, María Elisa
Vélaz, Itziar
Tánori, Judith
author_facet Rochín-Wong, Sarai
Rosas-Durazo, Aarón
Zavala-Rivera, Paul
Maldonado, Amir
Martínez-Barbosa, María Elisa
Vélaz, Itziar
Tánori, Judith
author_sort Rochín-Wong, Sarai
collection PubMed
description Engineering of multifunctional drug nanocarriers combining stability and good release properties remains a great challenge. In this work, natural polymers κ-carrageenan (κ-CAR) and chitosan (CS) were deposited onto olive oil nanoemulsion droplets (NE) via layer-by-layer (LbL) self-assembly to study the release mechanisms of the anti-inflammatory diflunisal (DF) as a lipophilic drug model. The nano-systems were characterized by dynamic light scattering (DLS), zeta potential (ζ-potential) measurements, transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray energy dispersive spectroscopy (XEDS) and Fourier transform infrared spectroscopy (FTIR) to confirm the NE-coating with polymer layers. In addition, kinetic release studies of DF were developed by the dialysis diffusion bag technique. Mathematical models were applied to investigate the release mechanisms. The results showed that stable and suitably sized nanocapsules (~300 nm) were formed. Also, the consecutive adsorption of polyelectrolytes by charge reversal was evidenced. More interestingly, the drug release mechanism varied depending on the number of layers deposited. The nanosized systems containing up to two layers showed anomalous transport and first order kinetics. Formulations with three and four layers exhibited Case II transport releasing diflunisal with zero order kinetics. Hence, our results suggest that these polyelectrolyte nanocapsules have great potential as a multifunctional nanocarrier for drug delivery applications.
format Online
Article
Text
id pubmed-6403737
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-64037372019-04-02 Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers Rochín-Wong, Sarai Rosas-Durazo, Aarón Zavala-Rivera, Paul Maldonado, Amir Martínez-Barbosa, María Elisa Vélaz, Itziar Tánori, Judith Polymers (Basel) Article Engineering of multifunctional drug nanocarriers combining stability and good release properties remains a great challenge. In this work, natural polymers κ-carrageenan (κ-CAR) and chitosan (CS) were deposited onto olive oil nanoemulsion droplets (NE) via layer-by-layer (LbL) self-assembly to study the release mechanisms of the anti-inflammatory diflunisal (DF) as a lipophilic drug model. The nano-systems were characterized by dynamic light scattering (DLS), zeta potential (ζ-potential) measurements, transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray energy dispersive spectroscopy (XEDS) and Fourier transform infrared spectroscopy (FTIR) to confirm the NE-coating with polymer layers. In addition, kinetic release studies of DF were developed by the dialysis diffusion bag technique. Mathematical models were applied to investigate the release mechanisms. The results showed that stable and suitably sized nanocapsules (~300 nm) were formed. Also, the consecutive adsorption of polyelectrolytes by charge reversal was evidenced. More interestingly, the drug release mechanism varied depending on the number of layers deposited. The nanosized systems containing up to two layers showed anomalous transport and first order kinetics. Formulations with three and four layers exhibited Case II transport releasing diflunisal with zero order kinetics. Hence, our results suggest that these polyelectrolyte nanocapsules have great potential as a multifunctional nanocarrier for drug delivery applications. MDPI 2018-07-10 /pmc/articles/PMC6403737/ /pubmed/30960685 http://dx.doi.org/10.3390/polym10070760 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rochín-Wong, Sarai
Rosas-Durazo, Aarón
Zavala-Rivera, Paul
Maldonado, Amir
Martínez-Barbosa, María Elisa
Vélaz, Itziar
Tánori, Judith
Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers
title Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers
title_full Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers
title_fullStr Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers
title_full_unstemmed Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers
title_short Drug Release Properties of Diflunisal from Layer-By-Layer Self-Assembled κ-Carrageenan/Chitosan Nanocapsules: Effect of Deposited Layers
title_sort drug release properties of diflunisal from layer-by-layer self-assembled κ-carrageenan/chitosan nanocapsules: effect of deposited layers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403737/
https://www.ncbi.nlm.nih.gov/pubmed/30960685
http://dx.doi.org/10.3390/polym10070760
work_keys_str_mv AT rochinwongsarai drugreleasepropertiesofdiflunisalfromlayerbylayerselfassembledkcarrageenanchitosannanocapsuleseffectofdepositedlayers
AT rosasdurazoaaron drugreleasepropertiesofdiflunisalfromlayerbylayerselfassembledkcarrageenanchitosannanocapsuleseffectofdepositedlayers
AT zavalariverapaul drugreleasepropertiesofdiflunisalfromlayerbylayerselfassembledkcarrageenanchitosannanocapsuleseffectofdepositedlayers
AT maldonadoamir drugreleasepropertiesofdiflunisalfromlayerbylayerselfassembledkcarrageenanchitosannanocapsuleseffectofdepositedlayers
AT martinezbarbosamariaelisa drugreleasepropertiesofdiflunisalfromlayerbylayerselfassembledkcarrageenanchitosannanocapsuleseffectofdepositedlayers
AT velazitziar drugreleasepropertiesofdiflunisalfromlayerbylayerselfassembledkcarrageenanchitosannanocapsuleseffectofdepositedlayers
AT tanorijudith drugreleasepropertiesofdiflunisalfromlayerbylayerselfassembledkcarrageenanchitosannanocapsuleseffectofdepositedlayers