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Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas
In this work, a new class of highly stretchable peptide-polyurethane/ureas (PUUs) were synthesized containing short β-sheet forming peptide blocks of poly(γ-benzyl-l-glutamate)-b-poly(propylene glycol)-b-poly(γ-benzyl-l-glutamate) (PBLG-b-PPG-b-PBLG), isophorone diisocyanate as the hard segment, and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403790/ https://www.ncbi.nlm.nih.gov/pubmed/30966671 http://dx.doi.org/10.3390/polym10060637 |
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author | Gu, Lin Jiang, Yuanzhang Hu, Jinlian |
author_facet | Gu, Lin Jiang, Yuanzhang Hu, Jinlian |
author_sort | Gu, Lin |
collection | PubMed |
description | In this work, a new class of highly stretchable peptide-polyurethane/ureas (PUUs) were synthesized containing short β-sheet forming peptide blocks of poly(γ-benzyl-l-glutamate)-b-poly(propylene glycol)-b-poly(γ-benzyl-l-glutamate) (PBLG-b-PPG-b-PBLG), isophorone diisocyanate as the hard segment, and polytetramethylene ether glycol as the soft phase. PBLG-b-PPG-b-PBLG with short peptide segment length (<10 residues) was synthesized by amine-initiated ring opening polymerization of γ-benzyl-l-glutamate-N-carboxyanhydrides (BLG-NCA), which shows mixed α-helix and β-sheet conformation, where the percent of β-sheet structure was above 48%. Morphological studies indicate that the obtained PUUs show β-sheet crystal and nanofibrous structure. Mechanical tests reveal the PUUs display medium tensile strength (0.25–4.6 MPa), high stretchability (>1600%), human-tissue-compatible Young’s modulus (226–513 KPa). Furthermore, the shape recovery ratio could reach above 85% during successive cycles at high strain (500%). In this study, we report a facile synthetic method to obtain highly stretchable and recovery peptide-polyurethane/urea materials, which will have various potential applications such as wearable and implantable electronics, and biomedical devices. |
format | Online Article Text |
id | pubmed-6403790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64037902019-04-02 Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas Gu, Lin Jiang, Yuanzhang Hu, Jinlian Polymers (Basel) Article In this work, a new class of highly stretchable peptide-polyurethane/ureas (PUUs) were synthesized containing short β-sheet forming peptide blocks of poly(γ-benzyl-l-glutamate)-b-poly(propylene glycol)-b-poly(γ-benzyl-l-glutamate) (PBLG-b-PPG-b-PBLG), isophorone diisocyanate as the hard segment, and polytetramethylene ether glycol as the soft phase. PBLG-b-PPG-b-PBLG with short peptide segment length (<10 residues) was synthesized by amine-initiated ring opening polymerization of γ-benzyl-l-glutamate-N-carboxyanhydrides (BLG-NCA), which shows mixed α-helix and β-sheet conformation, where the percent of β-sheet structure was above 48%. Morphological studies indicate that the obtained PUUs show β-sheet crystal and nanofibrous structure. Mechanical tests reveal the PUUs display medium tensile strength (0.25–4.6 MPa), high stretchability (>1600%), human-tissue-compatible Young’s modulus (226–513 KPa). Furthermore, the shape recovery ratio could reach above 85% during successive cycles at high strain (500%). In this study, we report a facile synthetic method to obtain highly stretchable and recovery peptide-polyurethane/urea materials, which will have various potential applications such as wearable and implantable electronics, and biomedical devices. MDPI 2018-06-08 /pmc/articles/PMC6403790/ /pubmed/30966671 http://dx.doi.org/10.3390/polym10060637 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gu, Lin Jiang, Yuanzhang Hu, Jinlian Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas |
title | Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas |
title_full | Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas |
title_fullStr | Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas |
title_full_unstemmed | Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas |
title_short | Facile Preparation of Highly Stretchable and Recovery Peptide-Polyurethane/Ureas |
title_sort | facile preparation of highly stretchable and recovery peptide-polyurethane/ureas |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403790/ https://www.ncbi.nlm.nih.gov/pubmed/30966671 http://dx.doi.org/10.3390/polym10060637 |
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