Hyaluronic Acid-Based Nanomaterials for Cancer Therapy

Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan and a major component of the extracellular matrix. HA is overexpressed by numerous tumor cells, especially tumor-initiating cells. HA-based nanomaterials play in importance role in drug delivery systems. HA is used in various types of nanomater...

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Autores principales: Kim, Jin Hong, Moon, Myeong Ju, Kim, Dong Yi, Heo, Suk Hee, Jeong, Yong Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403826/
https://www.ncbi.nlm.nih.gov/pubmed/30961058
http://dx.doi.org/10.3390/polym10101133
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author Kim, Jin Hong
Moon, Myeong Ju
Kim, Dong Yi
Heo, Suk Hee
Jeong, Yong Yeon
author_facet Kim, Jin Hong
Moon, Myeong Ju
Kim, Dong Yi
Heo, Suk Hee
Jeong, Yong Yeon
author_sort Kim, Jin Hong
collection PubMed
description Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan and a major component of the extracellular matrix. HA is overexpressed by numerous tumor cells, especially tumor-initiating cells. HA-based nanomaterials play in importance role in drug delivery systems. HA is used in various types of nanomaterials including micelle, polymersome, hydrogel, and inorganic nanoparticle formulations. Many experiments show that HA-based nanomaterials can serve as a platform for targeted chemotherapy, gene therapy, immunotherapy, and combination therapy with good potential for future biomedical applications in cancer treatment.
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spelling pubmed-64038262019-04-02 Hyaluronic Acid-Based Nanomaterials for Cancer Therapy Kim, Jin Hong Moon, Myeong Ju Kim, Dong Yi Heo, Suk Hee Jeong, Yong Yeon Polymers (Basel) Review Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan and a major component of the extracellular matrix. HA is overexpressed by numerous tumor cells, especially tumor-initiating cells. HA-based nanomaterials play in importance role in drug delivery systems. HA is used in various types of nanomaterials including micelle, polymersome, hydrogel, and inorganic nanoparticle formulations. Many experiments show that HA-based nanomaterials can serve as a platform for targeted chemotherapy, gene therapy, immunotherapy, and combination therapy with good potential for future biomedical applications in cancer treatment. MDPI 2018-10-12 /pmc/articles/PMC6403826/ /pubmed/30961058 http://dx.doi.org/10.3390/polym10101133 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kim, Jin Hong
Moon, Myeong Ju
Kim, Dong Yi
Heo, Suk Hee
Jeong, Yong Yeon
Hyaluronic Acid-Based Nanomaterials for Cancer Therapy
title Hyaluronic Acid-Based Nanomaterials for Cancer Therapy
title_full Hyaluronic Acid-Based Nanomaterials for Cancer Therapy
title_fullStr Hyaluronic Acid-Based Nanomaterials for Cancer Therapy
title_full_unstemmed Hyaluronic Acid-Based Nanomaterials for Cancer Therapy
title_short Hyaluronic Acid-Based Nanomaterials for Cancer Therapy
title_sort hyaluronic acid-based nanomaterials for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403826/
https://www.ncbi.nlm.nih.gov/pubmed/30961058
http://dx.doi.org/10.3390/polym10101133
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