Cargando…
Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions
In this work, host–guest supramolecular hydrogels were prepared from poly(N-isopropylacrylamide) (pNIPAm) microgels utilizing electrostatic and host/guest self-assembly. First, pNIPAm microgels bearing a poly(acrylic acid) (pAAc) shell were coated with positively charged β-cyclodextrin polymers. Add...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403914/ https://www.ncbi.nlm.nih.gov/pubmed/30966600 http://dx.doi.org/10.3390/polym10060566 |
_version_ | 1783400740565286912 |
---|---|
author | Antoniuk, Iurii Kaczmarek, Daria Kardos, Attila Varga, Imre Amiel, Catherine |
author_facet | Antoniuk, Iurii Kaczmarek, Daria Kardos, Attila Varga, Imre Amiel, Catherine |
author_sort | Antoniuk, Iurii |
collection | PubMed |
description | In this work, host–guest supramolecular hydrogels were prepared from poly(N-isopropylacrylamide) (pNIPAm) microgels utilizing electrostatic and host/guest self-assembly. First, pNIPAm microgels bearing a poly(acrylic acid) (pAAc) shell were coated with positively charged β-cyclodextrin polymers. Addition of adamantane-substituted dextrans (Dex-Ada) allowed us to establish interparticle connections through β-cyclodextrin-adamantane (βCD-Ada) inclusion complex formation, and thus to prepare hierarchical hydrogels. Under the conditions of hydrogel formation, close contact between the microgels was ensured. To the best of our knowledge, this is the first example of doubly crosslinked microgels prepared by noncovalent crosslinking via host–guest interactions. The prepared macrogels were studied with rheology, and fast mechanical response to temperature variation was found. Furthermore, the hydrogels exhibit fully reversible temperature-induced gel–sol transition at the physiological temperature range (37–41 °C), due to the synergetic effect between shrinking of the microgels and dissociation of βCD-Ada crosslinks at higher temperatures. This opens up attractive prospects of their potential use in biomedical applications. |
format | Online Article Text |
id | pubmed-6403914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64039142019-04-02 Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions Antoniuk, Iurii Kaczmarek, Daria Kardos, Attila Varga, Imre Amiel, Catherine Polymers (Basel) Article In this work, host–guest supramolecular hydrogels were prepared from poly(N-isopropylacrylamide) (pNIPAm) microgels utilizing electrostatic and host/guest self-assembly. First, pNIPAm microgels bearing a poly(acrylic acid) (pAAc) shell were coated with positively charged β-cyclodextrin polymers. Addition of adamantane-substituted dextrans (Dex-Ada) allowed us to establish interparticle connections through β-cyclodextrin-adamantane (βCD-Ada) inclusion complex formation, and thus to prepare hierarchical hydrogels. Under the conditions of hydrogel formation, close contact between the microgels was ensured. To the best of our knowledge, this is the first example of doubly crosslinked microgels prepared by noncovalent crosslinking via host–guest interactions. The prepared macrogels were studied with rheology, and fast mechanical response to temperature variation was found. Furthermore, the hydrogels exhibit fully reversible temperature-induced gel–sol transition at the physiological temperature range (37–41 °C), due to the synergetic effect between shrinking of the microgels and dissociation of βCD-Ada crosslinks at higher temperatures. This opens up attractive prospects of their potential use in biomedical applications. MDPI 2018-05-23 /pmc/articles/PMC6403914/ /pubmed/30966600 http://dx.doi.org/10.3390/polym10060566 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Antoniuk, Iurii Kaczmarek, Daria Kardos, Attila Varga, Imre Amiel, Catherine Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions |
title | Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions |
title_full | Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions |
title_fullStr | Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions |
title_full_unstemmed | Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions |
title_short | Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions |
title_sort | supramolecular hydrogel based on pnipam microgels connected via host–guest interactions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403914/ https://www.ncbi.nlm.nih.gov/pubmed/30966600 http://dx.doi.org/10.3390/polym10060566 |
work_keys_str_mv | AT antoniukiurii supramolecularhydrogelbasedonpnipammicrogelsconnectedviahostguestinteractions AT kaczmarekdaria supramolecularhydrogelbasedonpnipammicrogelsconnectedviahostguestinteractions AT kardosattila supramolecularhydrogelbasedonpnipammicrogelsconnectedviahostguestinteractions AT vargaimre supramolecularhydrogelbasedonpnipammicrogelsconnectedviahostguestinteractions AT amielcatherine supramolecularhydrogelbasedonpnipammicrogelsconnectedviahostguestinteractions |