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Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions

In this work, host–guest supramolecular hydrogels were prepared from poly(N-isopropylacrylamide) (pNIPAm) microgels utilizing electrostatic and host/guest self-assembly. First, pNIPAm microgels bearing a poly(acrylic acid) (pAAc) shell were coated with positively charged β-cyclodextrin polymers. Add...

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Autores principales: Antoniuk, Iurii, Kaczmarek, Daria, Kardos, Attila, Varga, Imre, Amiel, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403914/
https://www.ncbi.nlm.nih.gov/pubmed/30966600
http://dx.doi.org/10.3390/polym10060566
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author Antoniuk, Iurii
Kaczmarek, Daria
Kardos, Attila
Varga, Imre
Amiel, Catherine
author_facet Antoniuk, Iurii
Kaczmarek, Daria
Kardos, Attila
Varga, Imre
Amiel, Catherine
author_sort Antoniuk, Iurii
collection PubMed
description In this work, host–guest supramolecular hydrogels were prepared from poly(N-isopropylacrylamide) (pNIPAm) microgels utilizing electrostatic and host/guest self-assembly. First, pNIPAm microgels bearing a poly(acrylic acid) (pAAc) shell were coated with positively charged β-cyclodextrin polymers. Addition of adamantane-substituted dextrans (Dex-Ada) allowed us to establish interparticle connections through β-cyclodextrin-adamantane (βCD-Ada) inclusion complex formation, and thus to prepare hierarchical hydrogels. Under the conditions of hydrogel formation, close contact between the microgels was ensured. To the best of our knowledge, this is the first example of doubly crosslinked microgels prepared by noncovalent crosslinking via host–guest interactions. The prepared macrogels were studied with rheology, and fast mechanical response to temperature variation was found. Furthermore, the hydrogels exhibit fully reversible temperature-induced gel–sol transition at the physiological temperature range (37–41 °C), due to the synergetic effect between shrinking of the microgels and dissociation of βCD-Ada crosslinks at higher temperatures. This opens up attractive prospects of their potential use in biomedical applications.
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spelling pubmed-64039142019-04-02 Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions Antoniuk, Iurii Kaczmarek, Daria Kardos, Attila Varga, Imre Amiel, Catherine Polymers (Basel) Article In this work, host–guest supramolecular hydrogels were prepared from poly(N-isopropylacrylamide) (pNIPAm) microgels utilizing electrostatic and host/guest self-assembly. First, pNIPAm microgels bearing a poly(acrylic acid) (pAAc) shell were coated with positively charged β-cyclodextrin polymers. Addition of adamantane-substituted dextrans (Dex-Ada) allowed us to establish interparticle connections through β-cyclodextrin-adamantane (βCD-Ada) inclusion complex formation, and thus to prepare hierarchical hydrogels. Under the conditions of hydrogel formation, close contact between the microgels was ensured. To the best of our knowledge, this is the first example of doubly crosslinked microgels prepared by noncovalent crosslinking via host–guest interactions. The prepared macrogels were studied with rheology, and fast mechanical response to temperature variation was found. Furthermore, the hydrogels exhibit fully reversible temperature-induced gel–sol transition at the physiological temperature range (37–41 °C), due to the synergetic effect between shrinking of the microgels and dissociation of βCD-Ada crosslinks at higher temperatures. This opens up attractive prospects of their potential use in biomedical applications. MDPI 2018-05-23 /pmc/articles/PMC6403914/ /pubmed/30966600 http://dx.doi.org/10.3390/polym10060566 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Antoniuk, Iurii
Kaczmarek, Daria
Kardos, Attila
Varga, Imre
Amiel, Catherine
Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions
title Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions
title_full Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions
title_fullStr Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions
title_full_unstemmed Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions
title_short Supramolecular Hydrogel Based on pNIPAm Microgels Connected via Host–Guest Interactions
title_sort supramolecular hydrogel based on pnipam microgels connected via host–guest interactions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403914/
https://www.ncbi.nlm.nih.gov/pubmed/30966600
http://dx.doi.org/10.3390/polym10060566
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