Cargando…
A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone)
In the last decades bioresorbable and biodegradable polymers have gained a very good reputation both in research and in industry thanks to their unique characteristics. They are able to ensure high performance and biocompatibility, at the same time avoiding post-healing surgical interventions for de...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403915/ https://www.ncbi.nlm.nih.gov/pubmed/30960776 http://dx.doi.org/10.3390/polym10080851 |
_version_ | 1783400740798070784 |
---|---|
author | Cingolani, Alberto Casalini, Tommaso Caimi, Stefano Klaue, Antoine Sponchioni, Mattia Rossi, Filippo Perale, Giuseppe |
author_facet | Cingolani, Alberto Casalini, Tommaso Caimi, Stefano Klaue, Antoine Sponchioni, Mattia Rossi, Filippo Perale, Giuseppe |
author_sort | Cingolani, Alberto |
collection | PubMed |
description | In the last decades bioresorbable and biodegradable polymers have gained a very good reputation both in research and in industry thanks to their unique characteristics. They are able to ensure high performance and biocompatibility, at the same time avoiding post-healing surgical interventions for device removal. In the medical device industry, it is widely known that product formulation and manufacturing need to follow specific procedures in order to ensure both the proper mechanical properties and desired degradation profile. Moreover, the sterilization method is crucial and its impact on physical properties is generally underestimated. In this work we focused our attention on the effect of different terminal sterilization methods on two commercially available poly(l-lactide-co-ε-caprolactone) with equivalent chemical composition (70% PLA and 30% PCL) and relatively similar initial molecular weights, but different chain arrangements and crystallinity. Results obtained show that crystallinity plays a key role in helping preserve the narrow distribution of chains and, as a consequence, defined physical properties. These statements can be used as guidelines for a better choice of the most adequate biodegradable polymers in the production of resorbable medical devices. |
format | Online Article Text |
id | pubmed-6403915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64039152019-04-02 A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) Cingolani, Alberto Casalini, Tommaso Caimi, Stefano Klaue, Antoine Sponchioni, Mattia Rossi, Filippo Perale, Giuseppe Polymers (Basel) Article In the last decades bioresorbable and biodegradable polymers have gained a very good reputation both in research and in industry thanks to their unique characteristics. They are able to ensure high performance and biocompatibility, at the same time avoiding post-healing surgical interventions for device removal. In the medical device industry, it is widely known that product formulation and manufacturing need to follow specific procedures in order to ensure both the proper mechanical properties and desired degradation profile. Moreover, the sterilization method is crucial and its impact on physical properties is generally underestimated. In this work we focused our attention on the effect of different terminal sterilization methods on two commercially available poly(l-lactide-co-ε-caprolactone) with equivalent chemical composition (70% PLA and 30% PCL) and relatively similar initial molecular weights, but different chain arrangements and crystallinity. Results obtained show that crystallinity plays a key role in helping preserve the narrow distribution of chains and, as a consequence, defined physical properties. These statements can be used as guidelines for a better choice of the most adequate biodegradable polymers in the production of resorbable medical devices. MDPI 2018-08-01 /pmc/articles/PMC6403915/ /pubmed/30960776 http://dx.doi.org/10.3390/polym10080851 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cingolani, Alberto Casalini, Tommaso Caimi, Stefano Klaue, Antoine Sponchioni, Mattia Rossi, Filippo Perale, Giuseppe A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) |
title | A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) |
title_full | A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) |
title_fullStr | A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) |
title_full_unstemmed | A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) |
title_short | A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone) |
title_sort | methodologic approach for the selection of bio-resorbable polymers in the development of medical devices: the case of poly(l-lactide-co-ε-caprolactone) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403915/ https://www.ncbi.nlm.nih.gov/pubmed/30960776 http://dx.doi.org/10.3390/polym10080851 |
work_keys_str_mv | AT cingolanialberto amethodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT casalinitommaso amethodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT caimistefano amethodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT klaueantoine amethodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT sponchionimattia amethodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT rossifilippo amethodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT peralegiuseppe amethodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT cingolanialberto methodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT casalinitommaso methodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT caimistefano methodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT klaueantoine methodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT sponchionimattia methodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT rossifilippo methodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone AT peralegiuseppe methodologicapproachfortheselectionofbioresorbablepolymersinthedevelopmentofmedicaldevicesthecaseofpolyllactidecoecaprolactone |