Cargando…

Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma

Extramedullary plasmacytoma is a type of plasma cell dyscrasia that can present as solitary tumor or secondary to multiple myeloma. We experienced a case of intramuscular plasmacytoma in the left thigh muscles of a patient secondary to multiple myeloma. A 73-year-old male with relapsed multiple myel...

Descripción completa

Detalles Bibliográficos
Autores principales: Sardar, Muhammad, Shaikh, Nasreen, Malik, Saad Ullah, Faridi, Warda, Balshan, Eli, Maniar, Mihir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404045/
https://www.ncbi.nlm.nih.gov/pubmed/30858972
http://dx.doi.org/10.1177/2050313X19833506
_version_ 1783400779708628992
author Sardar, Muhammad
Shaikh, Nasreen
Malik, Saad Ullah
Faridi, Warda
Balshan, Eli
Maniar, Mihir
author_facet Sardar, Muhammad
Shaikh, Nasreen
Malik, Saad Ullah
Faridi, Warda
Balshan, Eli
Maniar, Mihir
author_sort Sardar, Muhammad
collection PubMed
description Extramedullary plasmacytoma is a type of plasma cell dyscrasia that can present as solitary tumor or secondary to multiple myeloma. We experienced a case of intramuscular plasmacytoma in the left thigh muscles of a patient secondary to multiple myeloma. A 73-year-old male with relapsed multiple myeloma and bilateral hip arthroplasty complained of lxeft lower limb weakness and hip pain 3 months after relapse. He underwent contrast-enhanced magnetic resonance imaging of lumbar spine and hip which was inconclusive. Subsequently, patient had multiple admissions for progressive lower limb weakness. His clinical course was complicated by a biopsy-proven plasmacytoma of the neck. He received localized radiation therapy to the neck in addition to a change in multiple myeloma chemotherapy regimen, resulting in resolution of the neck mass but his left lower extremity weakness continued to worsen. Repeat magnetic resonance imaging of hip and spine revealed an intramuscular mass in left thigh which was consistent with the diagnosis of extramedullary plasmacytoma on biopsy. Localized radiation to the thigh accompanied with a change in chemotherapy improved his symptoms and a significant reduction in size of plasmacytoma was observed. When an unexplained lower limb weakness is encountered with a history of multiple myeloma, secondary intramuscular plasmacytoma should be considered.
format Online
Article
Text
id pubmed-6404045
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-64040452019-03-11 Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma Sardar, Muhammad Shaikh, Nasreen Malik, Saad Ullah Faridi, Warda Balshan, Eli Maniar, Mihir SAGE Open Med Case Rep Case Report Extramedullary plasmacytoma is a type of plasma cell dyscrasia that can present as solitary tumor or secondary to multiple myeloma. We experienced a case of intramuscular plasmacytoma in the left thigh muscles of a patient secondary to multiple myeloma. A 73-year-old male with relapsed multiple myeloma and bilateral hip arthroplasty complained of lxeft lower limb weakness and hip pain 3 months after relapse. He underwent contrast-enhanced magnetic resonance imaging of lumbar spine and hip which was inconclusive. Subsequently, patient had multiple admissions for progressive lower limb weakness. His clinical course was complicated by a biopsy-proven plasmacytoma of the neck. He received localized radiation therapy to the neck in addition to a change in multiple myeloma chemotherapy regimen, resulting in resolution of the neck mass but his left lower extremity weakness continued to worsen. Repeat magnetic resonance imaging of hip and spine revealed an intramuscular mass in left thigh which was consistent with the diagnosis of extramedullary plasmacytoma on biopsy. Localized radiation to the thigh accompanied with a change in chemotherapy improved his symptoms and a significant reduction in size of plasmacytoma was observed. When an unexplained lower limb weakness is encountered with a history of multiple myeloma, secondary intramuscular plasmacytoma should be considered. SAGE Publications 2019-03-05 /pmc/articles/PMC6404045/ /pubmed/30858972 http://dx.doi.org/10.1177/2050313X19833506 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Sardar, Muhammad
Shaikh, Nasreen
Malik, Saad Ullah
Faridi, Warda
Balshan, Eli
Maniar, Mihir
Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma
title Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma
title_full Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma
title_fullStr Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma
title_full_unstemmed Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma
title_short Progressive left lower extremity weakness in a patient with multiple myeloma: A diagnostic dilemma
title_sort progressive left lower extremity weakness in a patient with multiple myeloma: a diagnostic dilemma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404045/
https://www.ncbi.nlm.nih.gov/pubmed/30858972
http://dx.doi.org/10.1177/2050313X19833506
work_keys_str_mv AT sardarmuhammad progressiveleftlowerextremityweaknessinapatientwithmultiplemyelomaadiagnosticdilemma
AT shaikhnasreen progressiveleftlowerextremityweaknessinapatientwithmultiplemyelomaadiagnosticdilemma
AT maliksaadullah progressiveleftlowerextremityweaknessinapatientwithmultiplemyelomaadiagnosticdilemma
AT faridiwarda progressiveleftlowerextremityweaknessinapatientwithmultiplemyelomaadiagnosticdilemma
AT balshaneli progressiveleftlowerextremityweaknessinapatientwithmultiplemyelomaadiagnosticdilemma
AT maniarmihir progressiveleftlowerextremityweaknessinapatientwithmultiplemyelomaadiagnosticdilemma