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8‐Aminoguanine Induces Diuresis, Natriuresis, and Glucosuria by Inhibiting Purine Nucleoside Phosphorylase and Reduces Potassium Excretion by Inhibiting Rac1

BACKGROUND: 8‐Aminoguanosine and 8‐aminoguanine are K(+)‐sparing natriuretics that increase glucose excretion. Most effects of 8‐aminoguanosine are due to its metabolism to 8‐aminoguanine. However, the mechanism by which 8‐aminoguanine affects renal function is unknown and is the focus of this inves...

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Detalles Bibliográficos
Autores principales:	Jackson, Edwin K., Mi, Zaichuan, Kleyman, Thomas R., Cheng, Dongmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404173/ https://www.ncbi.nlm.nih.gov/pubmed/30608204 http://dx.doi.org/10.1161/JAHA.118.010085

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