Estradiol Treatment Initiated Early After Ovariectomy Regulates Myocardial Gene Expression and Inhibits Diastolic Dysfunction in Female Cynomolgus Monkeys: Potential Roles for Calcium Homeostasis and Extracellular Matrix Remodeling

BACKGROUND: Left ventricular (LV) diastolic dysfunction often precedes heart failure with preserved ejection fraction, the dominant form of heart failure in postmenopausal women. The objective of this study was to determine the effect of oral estradiol treatment initiated early after ovariectomy on...

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Detalles Bibliográficos
Autores principales: Michalson, Kristofer T., Groban, Leanne, Howard, Timothy D., Shively, Carol A., Sophonsritsuk, Areepan, Appt, Susan E., Cline, J. Mark, Clarkson, Thomas B., Carr, J. Jeffrey, Kitzman, Dalane W., Register, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404177/
https://www.ncbi.nlm.nih.gov/pubmed/30571375
http://dx.doi.org/10.1161/JAHA.118.009769

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