Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras‐Induced ERK (Extracellular Signal‐Regulated Kinase) Signaling Pathway

BACKGROUND: Statins reduce aneurysm growth in mouse models of Marfan syndrome, although the mechanism is unknown. In addition to reducing cholesterol, statins block farnesylation and geranylgeranylation, which participate in membrane‐bound G‐protein signaling, including Ras. We dissected the prenyla...

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Detalles Bibliográficos
Autores principales: Sato, Tetsuya, Arakawa, Mamoru, Tashima, Yasushi, Tsuboi, Eitoshi, Burdon, Grayson, Trojan, Jeffrey, Koyano, Tiffany, Youn, Young‐Nam, Penov, Kiril, Pedroza, Albert J., Shabazzi, Mohammad, Palmon, Itai, Nguyen, Marie Noel, Connolly, Andrew J., Yamaguchi, Atsushi, Fischbein, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404178/
https://www.ncbi.nlm.nih.gov/pubmed/30571378
http://dx.doi.org/10.1161/JAHA.118.008543

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